hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080808/iprscan-20080808-08253873/chunk_1/iprscan-20080808-08253873.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: ef03333 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF00094.15.fs von Willebrand factor type D domain 617.2 6.9e-185 4 PF00094.15.ls von Willebrand factor type D domain 624.7 7.3e-185 4 PF08742.1.fs Domain of unknown function (DUF1787) 426.8 3e-151 4 PF00092.18.fs von Willebrand factor type A domain 416.5 1.4e-130 3 PF08742.1.ls Domain of unknown function (DUF1787) 434.3 1.5e-127 4 PF00092.18.ls von Willebrand factor type A domain 422.2 6.7e-124 3 PF00093.8.fs von Willebrand factor type C domain 319.6 5e-93 9 PF00093.8.ls von Willebrand factor type C domain 285.4 1e-82 5 PF01826.8.fs Trypsin Inhibitor like cysteine rich domain 150.0 1.8e-47 5 PF01826.8.ls Trypsin Inhibitor like cysteine rich domain 155.6 1.2e-43 5 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF00094.15.fs 1/4 61 205 .. 1 167 [] 133.7 7e-40 PF00094.15.ls 1/4 61 205 .. 1 167 [] 135.5 1.3e-37 PF08742.1.ls 1/4 244 318 .. 1 81 [] 100.4 5e-27 PF08742.1.fs 1/4 244 318 .. 1 81 [] 98.5 1.2e-34 PF01826.8.fs 1/5 321 374 .. 1 68 [] 41.5 8.6e-13 PF01826.8.ls 1/5 321 374 .. 1 68 [] 43.3 7.9e-10 PF00094.15.fs 2/4 414 567 .. 1 167 [] 190.1 8.8e-57 PF00094.15.ls 2/4 414 567 .. 1 167 [] 191.9 1.4e-54 PF08742.1.fs 2/4 603 675 .. 1 81 [] 114.5 2.5e-40 PF08742.1.ls 2/4 603 675 .. 1 81 [] 116.4 7.5e-32 PF01826.8.ls 2/5 678 733 .. 1 68 [] 44.6 3.1e-10 PF01826.8.fs 2/5 678 733 .. 1 68 [] 42.8 3.2e-13 PF02822.5.ls 1/2 709 735 .. 1 30 [] 1.3 1.6 PF02822.5.ls 2/2 830 855 .. 1 30 [] 2.5 1.2 PF05375.4.fs 2/2 863 890 .. 3 32 .. 10.0 0.086 PF00094.15.ls 3/4 893 1039 .. 1 167 [] 154.7 2.3e-43 PF00094.15.fs 3/4 893 1039 .. 1 167 [] 152.8 1.3e-45 PF08742.1.ls 3/4 1079 1153 .. 1 81 [] 117.0 4.9e-32 PF08742.1.fs 3/4 1079 1153 .. 1 81 [] 115.1 1.5e-40 PF01826.8.ls 4/5 1168 1222 .. 1 68 [] 33.4 7.6e-07 PF01826.8.fs 4/5 1172 1222 .. 7 68 .] 34.9 1.1e-10 PF00092.18.fs 1/3 1303 1483 .. 1 195 [] 117.0 1.2e-36 PF00092.18.ls 1/3 1303 1483 .. 1 195 [] 118.9 1.3e-32 PF00092.18.ls 2/3 1524 1690 .. 1 195 [] 159.4 8.8e-45 PF00092.18.fs 2/3 1524 1690 .. 1 195 [] 157.5 2.4e-49 PF00092.18.fs 3/3 1717 1890 .. 1 195 [] 142.0 1.7e-44 PF00092.18.ls 3/3 1717 1890 .. 1 195 [] 143.9 3.9e-40 PF00094.15.ls 4/4 1976 2128 .. 1 167 [] 142.5 1e-39 PF00094.15.fs 4/4 1976 2128 .. 1 167 [] 140.6 5.8e-42 PF08742.1.ls 4/4 2158 2226 .. 1 81 [] 100.5 4.8e-27 PF08742.1.fs 4/4 2158 2226 .. 1 81 [] 98.6 1.1e-34 PF00093.8.fs 5/9 2283 2351 .. 1 84 [] 89.2 5.5e-25 PF00093.8.ls 3/5 2283 2351 .. 1 84 [] 91.0 3.4e-24 PF00093.8.fs 7/9 2457 2520 .. 1 84 [] 90.6 2.1e-25 PF00093.8.ls 4/5 2457 2520 .. 1 84 [] 92.4 1.3e-24 PF00093.8.fs 9/9 2608 2670 .. 1 84 [] 79.2 3.9e-22 PF00093.8.ls 5/5 2608 2670 .. 1 84 [] 81.0 3.5e-21 Alignments of top-scoring domains: PF00094.15.fs: domain 1 of 4, from 61 to 205: score 133.7, E = 7e-40 *->CsvsGdphytTFDGvsYtfpgnCsYvlvlaqdcssesdffkfsvlnk Cs++G+ ++TFDG Y+f g CsY+ la c+ +s f+++ + ef03333 61 CSLFGSDFVNTFDGSMYSFAGYCSYL--LAGGCQKRS--FSIIGD-F 102 nvrcgssvtclksvtvilg.nveieltpgnadkdqvkVlvNgqevslslP ++ ++ s++v+lg+ ++i+l+++ ++V+ ++q+vs P ef03333 103 QNGKRV------SLSVYLGeFFDIHLFVN------GTVTQGDQRVSM--P 138 yssdngseikilgsgfllvalprlgvtlqfdwdgrtrlfvslspsyrgkt y s+++ +++ + +++ l+ ++g++ ++d++g +++v ls +y++kt ef03333 139 YASKGL-YLETEAGYYKLSGE-AYGFVARIDGSG--NFQVLLSDRYFNKT 184 cGLCGnfngepedDfrtpdGs<-* cGLCGnfn +edDf+t +G+ ef03333 185 CGLCGNFNIFAEDDFMTQEGT 205 PF00094.15.ls: domain 1 of 4, from 61 to 205: score 135.5, E = 1.3e-37 *->CsvsGdphytTFDGvsYtfpgnCsYvlvlaqdcssesdffkfsvlnk Cs++G+ ++TFDG Y+f g CsY+ la c+ +s f+++ + ef03333 61 CSLFGSDFVNTFDGSMYSFAGYCSYL--LAGGCQKRS--FSIIGD-F 102 nvrcgssvtclksvtvilg.nveieltpgnadkdqvkVlvNgqevslslP ++ ++ s++v+lg+ ++i+l+++ ++V+ ++q+vs P ef03333 103 QNGKRV------SLSVYLGeFFDIHLFVN------GTVTQGDQRVSM--P 138 yssdngseikilgsgfllvalprlgvtlqfdwdgrtrlfvslspsyrgkt y s+++ +++ + +++ l+ ++g++ ++d++g +++v ls +y++kt ef03333 139 YASKGL-YLETEAGYYKLSGE-AYGFVARIDGSG--NFQVLLSDRYFNKT 184 cGLCGnfngepedDfrtpdGs<-* cGLCGnfn +edDf+t +G+ ef03333 185 CGLCGNFNIFAEDDFMTQEGT 205 PF08742.1.ls: domain 1 of 4, from 244 to 318: score 100.4, E = 5e-27 *->eykaeeaCgiLlespvGPFaeCHsvVdPepfyeaCvyDlCacggggg ++ +e+C++L++ +v Fa+CH++VdPepf++ C lC+c+gg ef03333 244 QKGLWEQCQLLKSTSV--FARCHPLVDPEPFVALCEKTLCECAGG-- 286 deeclCsaLaaYAraCaaaGvcvdgWRtpttfCp<-* ec C+aL +YAr Ca++G +++gW ++ + C+ ef03333 287 -LECACPALLEYARTCAQEGMVLYGWTDH-SACS 318 PF08742.1.fs: domain 1 of 4, from 244 to 318: score 98.5, E = 1.2e-34 *->eykaeeaCgiLlespvGPFaeCHsvVdPepfyeaCvyDlCacggggg ++ +e+C++L++ +v Fa+CH++VdPepf++ C lC+c+gg ef03333 244 QKGLWEQCQLLKSTSV--FARCHPLVDPEPFVALCEKTLCECAGG-- 286 deeclCsaLaaYAraCaaaGvcvdgWRtpttfCp<-* ec C+aL +YAr Ca++G +++gW ++ + C+ ef03333 287 -LECACPALLEYARTCAQEGMVLYGWTDH-SACS 318 PF01826.8.fs: domain 1 of 5, from 321 to 374: score 41.5, E = 8.6e-13 *->CPaneqyteCgpsCepsCsnpdgplettppCegtSpkvPstCkegvC CPa +y+ C +C ++C++ + + +C C+ g C ef03333 321 CPAGMEYRQCVSPCARTCQSLHI----NEMCQ-------ERCVDG-C 355 vCqpGyVrnndgdkCVprseC<-* C++G+++++ CV+ +eC ef03333 356 SCPEGQLLDEG--LCVESTEC 374 PF01826.8.ls: domain 1 of 5, from 321 to 374: score 43.3, E = 7.9e-10 *->CPaneqyteCgpsCepsCsnpdgplettppCegtSpkvPstCkegvC CPa +y+ C +C ++C++ + + +C C+ g C ef03333 321 CPAGMEYRQCVSPCARTCQSLHI----NEMCQ-------ERCVDG-C 355 vCqpGyVrnndgdkCVprseC<-* C++G+++++ CV+ +eC ef03333 356 SCPEGQLLDEG--LCVESTEC 374 PF00094.15.fs: domain 2 of 4, from 414 to 567: score 190.1, E = 8.8e-57 *->CsvsGdphytTFDGvsYtfpgnCsYvlvlaqdcssesdffkfsvlnk C v G++h++ FD++++tf g C+Y+ la+dc+++s f++++++ ef03333 414 CLVTGQSHFKSFDNRYFTFSGICQYL--LARDCQDHS--FSIVIETV 456 nvrcgss.vtclksvtvilg...nveieltpgnadkdqvkVlvNgqevsl ++ ++ + v c++svtv+l++ +n ++l++g V +gq+v+l ef03333 457 QCADDRDaV-CTRSVTVRLPglhNSLVKLKHG------AGVAMDGQDVQL 499 slPyssdngseikilgsgfllvalprlgvtlqfdwdgrtrlfvslspsyr P+ + ++ +i+++ v+l ++g +lq+dwdgr+rl v+lsp y ef03333 500 --PLLKGDL-RIQRTV-T-ASVRL-SYGEDLQMDWDGRGRLLVKLSPVYA 543 gktcGLCGnfngepedDfrtpdGs<-* gktcGLCGn+ng++ dDf+tp+G ef03333 544 GKTCGLCGNYNGNQGDDFLTPSGL 567 PF00094.15.ls: domain 2 of 4, from 414 to 567: score 191.9, E = 1.4e-54 *->CsvsGdphytTFDGvsYtfpgnCsYvlvlaqdcssesdffkfsvlnk C v G++h++ FD++++tf g C+Y+ la+dc+++s f++++++ ef03333 414 CLVTGQSHFKSFDNRYFTFSGICQYL--LARDCQDHS--FSIVIETV 456 nvrcgss.vtclksvtvilg...nveieltpgnadkdqvkVlvNgqevsl ++ ++ + v c++svtv+l++ +n ++l++g V +gq+v+l ef03333 457 QCADDRDaV-CTRSVTVRLPglhNSLVKLKHG------AGVAMDGQDVQL 499 slPyssdngseikilgsgfllvalprlgvtlqfdwdgrtrlfvslspsyr P+ + ++ +i+++ v+l ++g +lq+dwdgr+rl v+lsp y ef03333 500 --PLLKGDL-RIQRTV-T-ASVRL-SYGEDLQMDWDGRGRLLVKLSPVYA 543 gktcGLCGnfngepedDfrtpdGs<-* gktcGLCGn+ng++ dDf+tp+G ef03333 544 GKTCGLCGNYNGNQGDDFLTPSGL 567 PF08742.1.fs: domain 2 of 4, from 603 to 675: score 114.5, E = 2.5e-40 *->eykaeeaCgiLlespvGPFaeCHsvVdPepfyeaCvyDlCacggggg + ++eeaC++L+ sp+ F++CH+ V+P p++++C+yD+C+c +g ef03333 603 TRFSEEACAVLT-SPT--FEACHRAVSPLPYLRNCRYDVCSCSDG-- 644 deeclCsaLaaYAraCaaaGvcvdgWRtpttfCp<-* +eclC aLa+YA+aCa +Gv v WR+p + C+ ef03333 645 -RECLCGALASYAAACAGRGVRVA-WREP-GRCE 675 PF08742.1.ls: domain 2 of 4, from 603 to 675: score 116.4, E = 7.5e-32 *->eykaeeaCgiLlespvGPFaeCHsvVdPepfyeaCvyDlCacggggg + ++eeaC++L+ sp+ F++CH+ V+P p++++C+yD+C+c +g ef03333 603 TRFSEEACAVLT-SPT--FEACHRAVSPLPYLRNCRYDVCSCSDG-- 644 deeclCsaLaaYAraCaaaGvcvdgWRtpttfCp<-* +eclC aLa+YA+aCa +Gv v WR+p + C+ ef03333 645 -RECLCGALASYAAACAGRGVRVA-WREP-GRCE 675 PF01826.8.ls: domain 2 of 5, from 678 to 733: score 44.6, E = 3.1e-10 *->CPaneqyteCgpsCepsCsnpdgplettppCegtSpkvPstCkegvC CP+ ++y Cg++C +C + + ++ C C eg C ef03333 678 CPKGQVYLQCGTPCNLTCRSLSY---PDEECN-------EACLEG-C 713 vCqpGyVrnndgdkCVprseC<-* C+pG +++++g +CVp+++C ef03333 714 FCPPGLYMDERG-DCVPKAQC 733 PF01826.8.fs: domain 2 of 5, from 678 to 733: score 42.8, E = 3.2e-13 *->CPaneqyteCgpsCepsCsnpdgplettppCegtSpkvPstCkegvC CP+ ++y Cg++C +C + + ++ C C eg C ef03333 678 CPKGQVYLQCGTPCNLTCRSLSY---PDEECN-------EACLEG-C 713 vCqpGyVrnndgdkCVprseC<-* C+pG +++++g +CVp+++C ef03333 714 FCPPGLYMDERG-DCVPKAQC 733 PF02822.5.ls: domain 1 of 2, from 709 to 735: score 1.3, E = 1.6 *->CeklqCskmfCpyGfvvDenG.CpAiatCkC<-* C C fCp G+ +De+G+C a C C ef03333 709 CLEG-C---FCPPGLYMDERGdCVPKAQCPC 735 PF02822.5.ls: domain 2 of 2, from 830 to 855: score 2.5, E = 1.2 *->CeklqCskmfCpyGfvvDenGCpAiatCkC<-* C + C +Cp G v+ en C A +C C ef03333 830 CVSG-C---LCPPGMVRHENRCVALERCPC 855 PF05375.4.fs: domain 2 of 2, from 863 to 890: score 10.0, E = 0.086 *->tPGsrwKdDCNwCtCtdgGtaavCTlkgCr<-* +PG++ K +CN+C C d + CT C+ ef03333 863 APGETVKIGCNTCVCRDR--KWNCTDHVCD 890 PF00094.15.ls: domain 3 of 4, from 893 to 1039: score 154.7, E = 2.3e-43 *->CsvsGdphytTFDGvsYtfpgnCsYvlvlaqdcssesdffkfsvlnk Cs+ G hy TFDG++Y fpg C+Yvlv+ ++c+s++ ++f++l++ ef03333 893 CSTIGMAHYLTFDGLKYLFPGECQYVLVQ-DYCGSNP--GTFRILVG 936 nvrcgss.vtclksvtvilgnveieltpgnadkdqvkVlvNgqevslslP n c+ ++v c k vt+ +++ eiel++g vN ++ P ef03333 937 NKGCSHPsVKCKKRVTILVEGGEIELFDG---------EVNVKR-----P 972 yssdngseikilgsgfllvalprlgvtlqfdwdgrtrlfvslspsyrgkt ++ d ++++ sg ++ l lg l++ wd +++++v+l ++y+ k+ ef03333 973 MK-DET-HFEVVESG-RYIIL-LLGKALSVVWDRHLSISVVLKQTYQEKV 1018 cGLCGnfngepedDfrtpdGs<-* cGLCGnf+g + +D+++++ ef03333 1019 CGLCGNFDGIQNNDLTSSNLQ 1039 PF00094.15.fs: domain 3 of 4, from 893 to 1039: score 152.8, E = 1.3e-45 *->CsvsGdphytTFDGvsYtfpgnCsYvlvlaqdcssesdffkfsvlnk Cs+ G hy TFDG++Y fpg C+Yvlv+ ++c+s++ ++f++l++ ef03333 893 CSTIGMAHYLTFDGLKYLFPGECQYVLVQ-DYCGSNP--GTFRILVG 936 nvrcgss.vtclksvtvilgnveieltpgnadkdqvkVlvNgqevslslP n c+ ++v c k vt+ +++ eiel++g vN ++ P ef03333 937 NKGCSHPsVKCKKRVTILVEGGEIELFDG---------EVNVKR-----P 972 yssdngseikilgsgfllvalprlgvtlqfdwdgrtrlfvslspsyrgkt ++ d ++++ sg ++ l lg l++ wd +++++v+l ++y+ k+ ef03333 973 MK-DET-HFEVVESG-RYIIL-LLGKALSVVWDRHLSISVVLKQTYQEKV 1018 cGLCGnfngepedDfrtpdGs<-* cGLCGnf+g + +D+++++ ef03333 1019 CGLCGNFDGIQNNDLTSSNLQ 1039 PF08742.1.ls: domain 3 of 4, from 1079 to 1153: score 117.0, E = 4.9e-32 *->eykaeeaCgiLlespvGPFaeCHsvVdPepfyeaCvyDlCacggggg ++ + + C+iL+ s+v F++C ++VdPep+++ C+yD+C+c+ g ef03333 1079 QTMVDSSCRILT-SDV--FQDCNKLVDPEPYLDVCIYDTCSCESI-G 1121 deeclCsaLaaYAraCaaaGvcvdgWRtpttfCp<-* d+ c+C+++aaYA+ Ca++G +v+ WRt t+Cp ef03333 1122 DCACFCDTIAAYAHVCAQHGKVVT-WRTA-TLCP 1153 PF08742.1.fs: domain 3 of 4, from 1079 to 1153: score 115.1, E = 1.5e-40 *->eykaeeaCgiLlespvGPFaeCHsvVdPepfyeaCvyDlCacggggg ++ + + C+iL+ s+v F++C ++VdPep+++ C+yD+C+c+ g ef03333 1079 QTMVDSSCRILT-SDV--FQDCNKLVDPEPYLDVCIYDTCSCESI-G 1121 deeclCsaLaaYAraCaaaGvcvdgWRtpttfCp<-* d+ c+C+++aaYA+ Ca++G +v+ WRt t+Cp ef03333 1122 DCACFCDTIAAYAHVCAQHGKVVT-WRTA-TLCP 1153 PF01826.8.ls: domain 4 of 5, from 1168 to 1222: score 33.4, E = 7.6e-07 *->CPaneqyteCgpsCepsCsnpdgplettppCegtSpkvPstCkegvC C+ y++C+p+C+++C++p+ + C+ +C+eg C ef03333 1168 CEW--RYNSCAPACQVTCQHPE-----PLACP-------VQCVEG-C 1199 v..CqpGyVrnndgdkCVprseC<-* +C+pG ++++ ++CV +++C ef03333 1200 HahCPPGKILDELLQTCVDPEDC 1222 PF01826.8.fs: domain 4 of 5, from 1172 to 1222: score 34.9, E = 1.1e-10 *->yteCgpsCepsCsnpdgplettppCegtSpkvPstCkegvCv..Cqp y++C+p+C+++C++p+ + C+ +C+eg C +C+p ef03333 1172 YNSCAPACQVTCQHPE-----PLACP-------VQCVEG-CHahCPP 1205 GyVrnndgdkCVprseC<-* G ++++ ++CV +++C ef03333 1206 GKILDELLQTCVDPEDC 1222 PF00092.18.fs: domain 1 of 3, from 1303 to 1483: score 117.0, E = 1.2e-36 *->DivFllDgSgSigeenlFekvkdFvkklveknldigpdgtrVglvqY D+vFllDgS+ ++e++ Fe k Fv++++e +l i+++ +rV++v Y ef03333 1303 DLVFLLDGSSRLSEAE-FEVLKAFVVDMME-RLRISQKWVRVAVVEY 1347 ssdvrtefsLndysskddllaavlknlrylgGgTnNtgkALkyalenlfs + + ++ L+d ++ ++l + ++ ++ + t + Lky+l ++fs ef03333 1348 HDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVAS-TSEVLKYTLFQIFS 1396 stMikrnrsagsRpenapkvlillTDGksndggsve.aaaalrdkkkgvg + +Rp +a+++++ll + +s + ++ kkk+v ef03333 1397 K---------IDRP-EASRIALLLMASQEPQRMSRNfVRYVQGLKKKKVI 1436 itvfavGvGgdvdeaeLr.iasepcseghvfyvedfdalwlqlqdiqeql ++++++G +++ +++r i + e+ +f +++ d+l+ q ++i++ l ef03333 1437 VIPVGIGP--HANLKQIRlIEKQA-PENKAFVLSSVDELEQQRDEIVSYL 1483 <-* ef03333 - - PF00092.18.ls: domain 1 of 3, from 1303 to 1483: score 118.9, E = 1.3e-32 *->DivFllDgSgSigeenlFekvkdFvkklveknldigpdgtrVglvqY D+vFllDgS+ ++e++ Fe k Fv++++e +l i+++ +rV++v Y ef03333 1303 DLVFLLDGSSRLSEAE-FEVLKAFVVDMME-RLRISQKWVRVAVVEY 1347 ssdvrtefsLndysskddllaavlknlrylgGgTnNtgkALkyalenlfs + + ++ L+d ++ ++l + ++ ++ + t + Lky+l ++fs ef03333 1348 HDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVAS-TSEVLKYTLFQIFS 1396 stMikrnrsagsRpenapkvlillTDGksndggsve.aaaalrdkkkgvg + +Rp +a+++++ll + +s + ++ kkk+v ef03333 1397 K---------IDRP-EASRIALLLMASQEPQRMSRNfVRYVQGLKKKKVI 1436 itvfavGvGgdvdeaeLr.iasepcseghvfyvedfdalwlqlqdiqeql ++++++G +++ +++r i + e+ +f +++ d+l+ q ++i++ l ef03333 1437 VIPVGIGP--HANLKQIRlIEKQA-PENKAFVLSSVDELEQQRDEIVSYL 1483 <-* ef03333 - - PF00092.18.ls: domain 2 of 3, from 1524 to 1690: score 159.4, E = 8.8e-45 *->DivFllDgSgSigeenlFekvkdFvkklveknldigpdgtrVglvqY D++F+l gS+ ige++ F++ k+F++++++ ++d+g+d+++V ++qY ef03333 1524 DVAFVLEGSDKIGEAD-FNRSKEFMEEVIQ-RMDVGQDSIHVTVLQY 1568 ssdvrtefsLndysskddllaavlknlrylgGgTnNtgkALkyalenlfs s+ v++e ++ +++sk+d+l++v +++ry gG+ Ntg+AL+y ++ f ef03333 1569 SYMVTVEYPFSEAQSKGDILQRV-REIRYQGGNRTNTGLALRYLSDHSFL 1617 stMikrnrsagsRpenapkvlillTDGksndggsveaaaalrdkkkgvgi s+g+R+ ap++++++T ++d+ +++ +i ef03333 1618 V-------SQGDRE-QAPNLVYMVTGNPASDE------IKRLPG----DI 1649 tvfavGvGgdvdeaeLr.iasepcseghvfyvedfdalwlqlqdiqeql< +v+ +GvG++++ +eL++i ++ + ++df+ l+ + +++l ef03333 1650 QVVPIGVGPNANVQELErIGWPN----APILIQDFET--LP--REAPDL 1690 -* ef03333 - - PF00092.18.fs: domain 2 of 3, from 1524 to 1690: score 157.5, E = 2.4e-49 *->DivFllDgSgSigeenlFekvkdFvkklveknldigpdgtrVglvqY D++F+l gS+ ige++ F++ k+F++++++ ++d+g+d+++V ++qY ef03333 1524 DVAFVLEGSDKIGEAD-FNRSKEFMEEVIQ-RMDVGQDSIHVTVLQY 1568 ssdvrtefsLndysskddllaavlknlrylgGgTnNtgkALkyalenlfs s+ v++e ++ +++sk+d+l++v +++ry gG+ Ntg+AL+y ++ f ef03333 1569 SYMVTVEYPFSEAQSKGDILQRV-REIRYQGGNRTNTGLALRYLSDHSFL 1617 stMikrnrsagsRpenapkvlillTDGksndggsveaaaalrdkkkgvgi s+g+R+ ap++++++T ++d+ +++ +i ef03333 1618 V-------SQGDRE-QAPNLVYMVTGNPASDE------IKRLPG----DI 1649 tvfavGvGgdvdeaeLr.iasepcseghvfyvedfdalwlqlqdiqeql< +v+ +GvG++++ +eL++i ++ + ++df+ l+ + +++l ef03333 1650 QVVPIGVGPNANVQELErIGWPN----APILIQDFET--LP--REAPDL 1690 -* ef03333 - - PF00092.18.fs: domain 3 of 3, from 1717 to 1890: score 142.0, E = 1.7e-44 *->DivFllDgSgSigeenlFekvkdFvkklveknldigpdgtrVglvqY D+++llDgS+S + F+++k F+k +++ + +igp+ t+V+++qY ef03333 1717 DVILLLDGSSSFPASY-FDEMKSFAKAFIS-KANIGPRLTQVSVLQY 1761 ssdvrtefsLndysskddllaavlknlrylgGgTnNtgkALkyalenlfs +s +++ ++ n +k++ll++v + ++ gG + +g+AL +a+++l+s ef03333 1762 GSITTIDVPWNVVPEKAHLLSLV-DVMQREGGPSQ-IGDALGFAVRYLTS 1809 stMikrnrsagsRpenapkvlillTDGksndggsve.aaaalrdkkkgvg + +g+Rp +a+k +++l s d+ v+ aa+a+r + + ef03333 1810 E-------MHGARP-GASKAVVILVTDVSVDS--VDaAADAARSN----R 1845 itvfavGvGgdvdeaeLr.iasepcseghvfyvedfdalwlqlqdiqeql +tvf +G+G+++d a+Lr +a++ +++v +++ ++ l+ +++ + ef03333 1846 VTVFPIGIGDRYDAAQLRiLAGPA-GDSNVVKLQRIED--LP--TMVTLG 1890 <-* ef03333 - - PF00092.18.ls: domain 3 of 3, from 1717 to 1890: score 143.9, E = 3.9e-40 *->DivFllDgSgSigeenlFekvkdFvkklveknldigpdgtrVglvqY D+++llDgS+S + F+++k F+k +++ + +igp+ t+V+++qY ef03333 1717 DVILLLDGSSSFPASY-FDEMKSFAKAFIS-KANIGPRLTQVSVLQY 1761 ssdvrtefsLndysskddllaavlknlrylgGgTnNtgkALkyalenlfs +s +++ ++ n +k++ll++v + ++ gG + +g+AL +a+++l+s ef03333 1762 GSITTIDVPWNVVPEKAHLLSLV-DVMQREGGPSQ-IGDALGFAVRYLTS 1809 stMikrnrsagsRpenapkvlillTDGksndggsve.aaaalrdkkkgvg + +g+Rp +a+k +++l s d+ v+ aa+a+r + + ef03333 1810 E-------MHGARP-GASKAVVILVTDVSVDS--VDaAADAARSN----R 1845 itvfavGvGgdvdeaeLr.iasepcseghvfyvedfdalwlqlqdiqeql +tvf +G+G+++d a+Lr +a++ +++v +++ ++ l+ +++ + ef03333 1846 VTVFPIGIGDRYDAAQLRiLAGPA-GDSNVVKLQRIED--LP--TMVTLG 1890 <-* ef03333 - - PF00094.15.ls: domain 4 of 4, from 1976 to 2128: score 142.5, E = 1e-39 *->CsvsGdphytTFDGvsYtfpgnCsYvlvlaqdcssesdffkfsvlnk C+ s+++h++TFDG+ ++ +g+CsYv l q + ++++++n+ ef03333 1976 CTGSSTRHIVTFDGQNFKLTGSCSYV--LFQNKEQD---LEVILHNG 2017 nvrcgss.vtclksvtvilgnveieltpgnadkdqvkVlvNgqevslslP +++g+ + c+ks+ v+++ + +el+ + ++V+vNg+ vs P ef03333 2018 ACSPGARqG-CMKSIEVKHSALSVELHSD------MEVTVNGRLVSV--P 2058 yssdngseikilgsgfllvalprlgvtlqfdwdg.rtrlfvslspsyrgk y+ n e++++g +++ v++++lg+ +f+ ++ ++l++s+ ++ k ef03333 2059 YVGGNM-EVNVYGAIMHEVRFNHLGHIFTFTPQNnEFQLQLSPKTFA-SK 2106 tcGLCGnfngepedDfrtpdGs<-* t+GLCG ++ + ++Df+++dG+ ef03333 2107 TYGLCGICDENGANDFMLRDGT 2128 PF00094.15.fs: domain 4 of 4, from 1976 to 2128: score 140.6, E = 5.8e-42 *->CsvsGdphytTFDGvsYtfpgnCsYvlvlaqdcssesdffkfsvlnk C+ s+++h++TFDG+ ++ +g+CsYv l q + ++++++n+ ef03333 1976 CTGSSTRHIVTFDGQNFKLTGSCSYV--LFQNKEQD---LEVILHNG 2017 nvrcgss.vtclksvtvilgnveieltpgnadkdqvkVlvNgqevslslP +++g+ + c+ks+ v+++ + +el+ + ++V+vNg+ vs P ef03333 2018 ACSPGARqG-CMKSIEVKHSALSVELHSD------MEVTVNGRLVSV--P 2058 yssdngseikilgsgfllvalprlgvtlqfdwdg.rtrlfvslspsyrgk y+ n e++++g +++ v++++lg+ +f+ ++ ++l++s+ ++ k ef03333 2059 YVGGNM-EVNVYGAIMHEVRFNHLGHIFTFTPQNnEFQLQLSPKTFA-SK 2106 tcGLCGnfngepedDfrtpdGs<-* t+GLCG ++ + ++Df+++dG+ ef03333 2107 TYGLCGICDENGANDFMLRDGT 2128 PF08742.1.ls: domain 4 of 4, from 2158 to 2226: score 100.5, E = 4.8e-27 *->eykaeeaCgiLlespvGPFaeCHsvVdPepfyeaCvyDlCacggggg + +++C++Ll p+ FaeCH+v++P+ fy+ C++D+C+ ++ ef03333 2158 LVPDSSHCQVLL-LPL--FAECHKVLAPATFYAICQQDSCHQEQV-- 2199 deeclCsaLaaYAraCaaaGvcvdgWRtpttfCp<-* C+++a+YA++C+ Gvcvd WRtp +fC+ ef03333 2200 -----CEVIASYAHLCRTNGVCVD-WRTP-DFCA 2226 PF08742.1.fs: domain 4 of 4, from 2158 to 2226: score 98.6, E = 1.1e-34 *->eykaeeaCgiLlespvGPFaeCHsvVdPepfyeaCvyDlCacggggg + +++C++Ll p+ FaeCH+v++P+ fy+ C++D+C+ ++ ef03333 2158 LVPDSSHCQVLL-LPL--FAECHKVLAPATFYAICQQDSCHQEQV-- 2199 deeclCsaLaaYAraCaaaGvcvdgWRtpttfCp<-* C+++a+YA++C+ Gvcvd WRtp +fC+ ef03333 2200 -----CEVIASYAHLCRTNGVCVD-WRTP-DFCA 2226 PF00093.8.fs: domain 5 of 9, from 2283 to 2351: score 89.2, E = 5.5e-25 *->Cv.qnGvvYengetWkpdsqPnGvdkCtyiCtCddiedavrlggkvl C++ +Gv++++ e W+pd+qP C+ iCtC++ g+kv+ ef03333 2283 CIgEDGVQHQFLEAWVPDHQP-----CQ-ICTCLS-------GRKVN 2316 CdkitCppel.LpsldCpnprrvdalvippGECCpewvC<-* C++++Cp+++ +++ C+ + +l+++ ++CCpe++C ef03333 2317 CTTQPCPTAKaPTCGLCEVA----RLRQNADQCCPEYEC 2351 PF00093.8.ls: domain 3 of 5, from 2283 to 2351: score 91.0, E = 3.4e-24 *->Cv.qnGvvYengetWkpdsqPnGvdkCtyiCtCddiedavrlggkvl C++ +Gv++++ e W+pd+qP C+ iCtC++ g+kv+ ef03333 2283 CIgEDGVQHQFLEAWVPDHQP-----CQ-ICTCLS-------GRKVN 2316 CdkitCppel.LpsldCpnprrvdalvippGECCpewvC<-* C++++Cp+++ +++ C+ + +l+++ ++CCpe++C ef03333 2317 CTTQPCPTAKaPTCGLCEVA----RLRQNADQCCPEYEC 2351 PF00093.8.fs: domain 7 of 9, from 2457 to 2520: score 90.6, E = 2.1e-25 *->CvqnGvvYengetWkpdsqPnGvdkCtyiCtCddiedavrlggkvlC Cv+++++Y+ g++W++ C+ +CtC+d+edav+++++ +C ef03333 2457 CVHRSTIYPVGQFWEEG--------CD-VCTCTDMEDAVMGLRVAQC 2494 dkitCppelLpsldCpnprrvdalvippGECCpewvC<-* ++++C+ ++C+++ +++v ++GECC+ +C ef03333 2495 SQKPCE------DSCRSG---FTYVLHEGECCG--RC 2520 PF00093.8.ls: domain 4 of 5, from 2457 to 2520: score 92.4, E = 1.3e-24 *->CvqnGvvYengetWkpdsqPnGvdkCtyiCtCddiedavrlggkvlC Cv+++++Y+ g++W++ C+ +CtC+d+edav+++++ +C ef03333 2457 CVHRSTIYPVGQFWEEG--------CD-VCTCTDMEDAVMGLRVAQC 2494 dkitCppelLpsldCpnprrvdalvippGECCpewvC<-* ++++C+ ++C+++ +++v ++GECC+ +C ef03333 2495 SQKPCE------DSCRSG---FTYVLHEGECCG--RC 2520 PF00093.8.fs: domain 9 of 9, from 2608 to 2670: score 79.2, E = 3.9e-22 *->CvqnGvvYengetWkpdsqPnGvdkCtyiCtCddiedavrlggkvlC C++nG+v+ +g+t ++d+ Ct +C+C+ ++++++ g+k +C ef03333 2608 CMLNGTVIGPGKTVMIDV-------CT-TCRCMVQVGVIS-GFKLEC 2645 dkitCppelLpsldCpnprrvdalvippGECCpewvC<-* +k+tC ++Cp + +++++++GECC+ +C ef03333 2646 RKTTC-------NPCPLG---YKEENNTGECCG--RC 2670 PF00093.8.ls: domain 5 of 5, from 2608 to 2670: score 81.0, E = 3.5e-21 *->CvqnGvvYengetWkpdsqPnGvdkCtyiCtCddiedavrlggkvlC C++nG+v+ +g+t ++d+ Ct +C+C+ ++++++ g+k +C ef03333 2608 CMLNGTVIGPGKTVMIDV-------CT-TCRCMVQVGVIS-GFKLEC 2645 dkitCppelLpsldCpnprrvdalvippGECCpewvC<-* +k+tC ++Cp + +++++++GECC+ +C ef03333 2646 RKTTC-------NPCPLG---YKEENNTGECCG--RC 2670 //