# /hgtech/tools/solaris8/bin/fasta34_t -T 8 -b50 -d10 -E0.01 -H -Ofh04042.fasta.nr -Q fh04042.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 fh04042, 712 aa vs /cdna2/lib/nr/nr library 2355815254 residues in 6825066 sequences statistics sampled from 60000 to 6806615 sequences Expectation_n fit: rho(ln(x))= 7.4856+/-0.000215; mu= 1.5927+/- 0.012 mean_var=182.5407+/-34.826, 0's: 47 Z-trim: 105 B-trim: 0 in 0/65 Lambda= 0.094928 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(6825066) gi|62088214|dbj|BAD92554.1| TCOF1 protein variant ( 712) 4514 631.0 3.8e-178 gi|119582141|gb|EAW61737.1| Treacher Collins-Franc (1021) 4435 620.4 8.8e-175 gi|32425436|gb|AAH27252.1| TCOF1 protein [Homo sap (1126) 4435 620.4 9.5e-175 gi|119582143|gb|EAW61739.1| Treacher Collins-Franc (1411) 4435 620.5 1.1e-174 gi|119582142|gb|EAW61738.1| Treacher Collins-Franc (1488) 4435 620.5 1.2e-174 gi|1587477|prf||2206473A TCOF1 gene (1359) 4424 619.0 3.1e-174 gi|1685049|gb|AAC51181.1| TCOF1 [Homo sapiens] (1411) 4424 619.0 3.2e-174 gi|1778432|gb|AAB40722.1| Treacher Collins syndrom (1411) 4424 619.0 3.2e-174 gi|122066350|sp|Q13428|TCOF_HUMAN Treacle protein (1488) 4424 619.0 3.3e-174 gi|114602823|ref|XP_527074.2| PREDICTED: Treacher (1411) 4214 590.2 1.4e-165 gi|119582140|gb|EAW61736.1| Treacher Collins-Franc (1409) 4209 589.5 2.3e-165 gi|117938784|gb|AAH16144.1| TCOF1 protein [Homo sa (1414) 4209 589.6 2.3e-165 gi|57164977|ref|NP_001008656.1| Treacher Collins-F (1450) 4209 589.6 2.4e-165 gi|15079955|gb|AAH11764.1| Treacher Collins-France ( 958) 3503 492.7 2.2e-136 gi|90265827|ref|NP_001035041.1| Treacher Collins-F (1485) 3104 438.2 8.6e-120 gi|71534846|gb|AAZ32817.1| treacle [Macaca mulatta (1007) 3094 436.7 1.7e-119 gi|149726178|ref|XP_001503770.1| PREDICTED: Treach (1424) 2819 399.2 4.7e-108 gi|119582137|gb|EAW61733.1| Treacher Collins-Franc ( 795) 2721 385.5 3.4e-104 gi|119582138|gb|EAW61734.1| Treacher Collins-Franc ( 872) 2721 385.6 3.6e-104 gi|149726180|ref|XP_001503774.1| PREDICTED: Treach (1389) 2683 380.6 1.9e-102 gi|119895727|ref|XP_591291.3| PREDICTED: similar t (1458) 1850 266.5 4.2e-68 gi|151554133|gb|AAI49188.1| TCOF1 protein [Bos tau (1353) 1848 266.2 4.9e-68 gi|119582136|gb|EAW61732.1| Treacher Collins-Franc ( 841) 1821 262.3 4.5e-67 gi|16605495|emb|CAC82741.1| treacle [Canis familia (1422) 930 140.5 3.5e-30 gi|16716330|emb|CAC88122.1| treacle [Canis familia ( 847) 916 138.4 9.2e-30 gi|71534848|gb|AAZ32818.1| treacle [Macaca mulatta ( 592) 713 110.4 1.7e-21 gi|116283930|gb|AAH46608.1| Tcof1 protein [Mus mus (1237) 679 106.1 7.1e-20 gi|148677851|gb|EDL09798.1| Treacher Collins Franc (1272) 679 106.1 7.3e-20 gi|149064373|gb|EDM14576.1| Treacher Collins Franc (1250) 654 102.6 7.7e-19 gi|148677855|gb|EDL09802.1| Treacher Collins Franc (1176) 607 96.2 6.4e-17 gi|2145149|gb|AAB60933.1| treacle [Mus musculus] (1302) 607 96.2 6.9e-17 gi|148677852|gb|EDL09799.1| Treacher Collins Franc (1302) 607 96.2 6.9e-17 gi|37805376|gb|AAH60105.1| Tcof1 protein [Mus musc (1314) 607 96.2 6.9e-17 gi|148677856|gb|EDL09803.1| Treacher Collins Franc (1320) 607 96.2 6.9e-17 gi|41688745|sp|O08784|TCOF_MOUSE Treacle protein ( (1320) 607 96.2 6.9e-17 gi|148677857|gb|EDL09804.1| Treacher Collins Franc (1279) 596 94.7 1.9e-16 gi|111307761|gb|AAI21193.1| Mki67 protein [Xenopus (2080) 575 92.0 2e-15 gi|70905643|gb|AAZ14282.1| proteophosphoglycan ppg (2425) 573 91.8 2.7e-15 gi|70905641|gb|AAZ14280.1| proteophosphoglycan ppg (7194) 563 90.9 1.5e-14 gi|47125144|gb|AAH70605.1| LOC431817 protein [Xeno (1196) 549 88.2 1.6e-14 gi|70905642|gb|AAZ14281.1| proteophosphoglycan 5 [ (17392) 569 92.1 1.6e-14 gi|34785731|gb|AAH57342.1| Tcof1 protein [Mus musc ( 942) 543 87.3 2.4e-14 gi|116283657|gb|AAH21514.1| Tcof1 protein [Mus mus (1013) 543 87.3 2.5e-14 gi|148677854|gb|EDL09801.1| Treacher Collins Franc (1038) 543 87.4 2.5e-14 gi|31807869|gb|AAH52669.1| Tcof1 protein [Mus musc (1320) 543 87.5 3e-14 gi|148677853|gb|EDL09800.1| Treacher Collins Franc (1356) 543 87.5 3.1e-14 gi|149412615|ref|XP_001510162.1| PREDICTED: simila (1294) 536 86.5 5.8e-14 gi|134073236|emb|CAM71958.1| proteophosphoglycan p (5967) 542 87.9 9.7e-14 gi|134065503|emb|CAM43270.1| proteophosphoglycan p (4324) 527 85.8 3.2e-13 gi|115700108|ref|XP_796224.2| PREDICTED: similar t ( 791) 512 83.0 4e-13 >>gi|62088214|dbj|BAD92554.1| TCOF1 protein variant [Hom (712 aa) initn: 4514 init1: 4514 opt: 4514 Z-score: 3353.5 bits: 631.0 E(): 3.8e-178 Smith-Waterman score: 4514; 100.000% identity (100.000% similar) in 712 aa overlap (1-712:1-712) 10 20 30 40 50 60 fh0404 AQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 AQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTG 10 20 30 40 50 60 70 80 90 100 110 120 fh0404 PAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 PAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKG 70 80 90 100 110 120 130 140 150 160 170 180 fh0404 AGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 AGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKP 130 140 150 160 170 180 190 200 210 220 230 240 fh0404 TSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 TSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQ 190 200 210 220 230 240 250 260 270 280 290 300 fh0404 TKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 TKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESD 250 260 270 280 290 300 310 320 330 340 350 360 fh0404 SEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 SEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE 310 320 330 340 350 360 370 380 390 400 410 420 fh0404 DSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 DSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAK 370 380 390 400 410 420 430 440 450 460 470 480 fh0404 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 430 440 450 460 470 480 490 500 510 520 530 540 fh0404 AETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 AETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESD 490 500 510 520 530 540 550 560 570 580 590 600 fh0404 SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSE 550 560 570 580 590 600 610 620 630 640 650 660 fh0404 SEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 SEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPAT 610 620 630 640 650 660 670 680 690 700 710 fh0404 QVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVSLGSQGKQAHGA :::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 QVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVSLGSQGKQAHGA 670 680 690 700 710 >>gi|119582141|gb|EAW61737.1| Treacher Collins-Francesch (1021 aa) initn: 4435 init1: 4435 opt: 4435 Z-score: 3293.0 bits: 620.4 E(): 8.8e-175 Smith-Waterman score: 4435; 100.000% identity (100.000% similar) in 700 aa overlap (1-700:204-903) 10 20 30 fh0404 AQAGKREEDSQSSSEESDSEEEAPAQAKPS :::::::::::::::::::::::::::::: gi|119 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 180 190 200 210 220 230 40 50 60 70 80 90 fh0404 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA 240 250 260 270 280 290 100 110 120 130 140 150 fh0404 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE 300 310 320 330 340 350 160 170 180 190 200 210 fh0404 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES 360 370 380 390 400 410 220 230 240 250 260 270 fh0404 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG 420 430 440 450 460 470 280 290 300 310 320 330 fh0404 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 480 490 500 510 520 530 340 350 360 370 380 390 fh0404 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 540 550 560 570 580 590 400 410 420 430 440 450 fh0404 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 600 610 620 630 640 650 460 470 480 490 500 510 fh0404 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 660 670 680 690 700 710 520 530 540 550 560 570 fh0404 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 720 730 740 750 760 770 580 590 600 610 620 630 fh0404 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 780 790 800 810 820 830 640 650 660 670 680 690 fh0404 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP 840 850 860 870 880 890 700 710 fh0404 VARTQPSSGVSLGSQGKQAHGA :::::::::: gi|119 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 900 910 920 930 940 950 >>gi|32425436|gb|AAH27252.1| TCOF1 protein [Homo sapiens (1126 aa) initn: 4435 init1: 4435 opt: 4435 Z-score: 3292.5 bits: 620.4 E(): 9.5e-175 Smith-Waterman score: 4435; 100.000% identity (100.000% similar) in 700 aa overlap (1-700:309-1008) 10 20 30 fh0404 AQAGKREEDSQSSSEESDSEEEAPAQAKPS :::::::::::::::::::::::::::::: gi|324 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 280 290 300 310 320 330 40 50 60 70 80 90 fh0404 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|324 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA 340 350 360 370 380 390 100 110 120 130 140 150 fh0404 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|324 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE 400 410 420 430 440 450 160 170 180 190 200 210 fh0404 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|324 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES 460 470 480 490 500 510 220 230 240 250 260 270 fh0404 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|324 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG 520 530 540 550 560 570 280 290 300 310 320 330 fh0404 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|324 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 580 590 600 610 620 630 340 350 360 370 380 390 fh0404 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|324 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 640 650 660 670 680 690 400 410 420 430 440 450 fh0404 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|324 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 700 710 720 730 740 750 460 470 480 490 500 510 fh0404 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|324 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 760 770 780 790 800 810 520 530 540 550 560 570 fh0404 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|324 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 820 830 840 850 860 870 580 590 600 610 620 630 fh0404 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|324 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 880 890 900 910 920 930 640 650 660 670 680 690 fh0404 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|324 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP 940 950 960 970 980 990 700 710 fh0404 VARTQPSSGVSLGSQGKQAHGA :::::::::: gi|324 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1000 1010 1020 1030 1040 1050 >>gi|119582143|gb|EAW61739.1| Treacher Collins-Francesch (1411 aa) initn: 4435 init1: 4435 opt: 4435 Z-score: 3291.2 bits: 620.5 E(): 1.1e-174 Smith-Waterman score: 4435; 100.000% identity (100.000% similar) in 700 aa overlap (1-700:324-1023) 10 20 30 fh0404 AQAGKREEDSQSSSEESDSEEEAPAQAKPS :::::::::::::::::::::::::::::: gi|119 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 300 310 320 330 340 350 40 50 60 70 80 90 fh0404 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA 360 370 380 390 400 410 100 110 120 130 140 150 fh0404 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE 420 430 440 450 460 470 160 170 180 190 200 210 fh0404 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES 480 490 500 510 520 530 220 230 240 250 260 270 fh0404 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG 540 550 560 570 580 590 280 290 300 310 320 330 fh0404 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 600 610 620 630 640 650 340 350 360 370 380 390 fh0404 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 660 670 680 690 700 710 400 410 420 430 440 450 fh0404 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 720 730 740 750 760 770 460 470 480 490 500 510 fh0404 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 780 790 800 810 820 830 520 530 540 550 560 570 fh0404 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 840 850 860 870 880 890 580 590 600 610 620 630 fh0404 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 900 910 920 930 940 950 640 650 660 670 680 690 fh0404 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP 960 970 980 990 1000 1010 700 710 fh0404 VARTQPSSGVSLGSQGKQAHGA :::::::::: gi|119 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1020 1030 1040 1050 1060 1070 >>gi|119582142|gb|EAW61738.1| Treacher Collins-Francesch (1488 aa) initn: 4435 init1: 4435 opt: 4435 Z-score: 3290.9 bits: 620.5 E(): 1.2e-174 Smith-Waterman score: 4435; 100.000% identity (100.000% similar) in 700 aa overlap (1-700:401-1100) 10 20 30 fh0404 AQAGKREEDSQSSSEESDSEEEAPAQAKPS :::::::::::::::::::::::::::::: gi|119 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 380 390 400 410 420 430 40 50 60 70 80 90 fh0404 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA 440 450 460 470 480 490 100 110 120 130 140 150 fh0404 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE 500 510 520 530 540 550 160 170 180 190 200 210 fh0404 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES 560 570 580 590 600 610 220 230 240 250 260 270 fh0404 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG 620 630 640 650 660 670 280 290 300 310 320 330 fh0404 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 680 690 700 710 720 730 340 350 360 370 380 390 fh0404 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 740 750 760 770 780 790 400 410 420 430 440 450 fh0404 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 800 810 820 830 840 850 460 470 480 490 500 510 fh0404 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 860 870 880 890 900 910 520 530 540 550 560 570 fh0404 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 920 930 940 950 960 970 580 590 600 610 620 630 fh0404 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 980 990 1000 1010 1020 1030 640 650 660 670 680 690 fh0404 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP 1040 1050 1060 1070 1080 1090 700 710 fh0404 VARTQPSSGVSLGSQGKQAHGA :::::::::: gi|119 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1100 1110 1120 1130 1140 1150 >>gi|1587477|prf||2206473A TCOF1 gene (1359 aa) initn: 4424 init1: 4424 opt: 4424 Z-score: 3283.3 bits: 619.0 E(): 3.1e-174 Smith-Waterman score: 4424; 99.714% identity (99.857% similar) in 700 aa overlap (1-700:307-1006) 10 20 30 fh0404 AQAGKREEDSQSSSEESDSEEEAPAQAKPS :::::::::::::::::::::::::::::: gi|158 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 280 290 300 310 320 330 40 50 60 70 80 90 fh0404 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA 340 350 360 370 380 390 100 110 120 130 140 150 fh0404 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE 400 410 420 430 440 450 160 170 180 190 200 210 fh0404 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES 460 470 480 490 500 510 220 230 240 250 260 270 fh0404 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: gi|158 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQPPRKAG 520 530 540 550 560 570 280 290 300 310 320 330 fh0404 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 580 590 600 610 620 630 340 350 360 370 380 390 fh0404 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 640 650 660 670 680 690 400 410 420 430 440 450 fh0404 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 700 710 720 730 740 750 460 470 480 490 500 510 fh0404 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|158 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQAKPSGKTHQIRAALAPAKESPRKG 760 770 780 790 800 810 520 530 540 550 560 570 fh0404 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 820 830 840 850 860 870 580 590 600 610 620 630 fh0404 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 880 890 900 910 920 930 640 650 660 670 680 690 fh0404 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP 940 950 960 970 980 990 700 710 fh0404 VARTQPSSGVSLGSQGKQAHGA :::::::::: gi|158 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1000 1010 1020 1030 1040 1050 >>gi|1685049|gb|AAC51181.1| TCOF1 [Homo sapiens] gi| (1411 aa) initn: 4424 init1: 4424 opt: 4424 Z-score: 3283.1 bits: 619.0 E(): 3.2e-174 Smith-Waterman score: 4424; 99.714% identity (99.857% similar) in 700 aa overlap (1-700:324-1023) 10 20 30 fh0404 AQAGKREEDSQSSSEESDSEEEAPAQAKPS :::::::::::::::::::::::::::::: gi|168 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 300 310 320 330 340 350 40 50 60 70 80 90 fh0404 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA 360 370 380 390 400 410 100 110 120 130 140 150 fh0404 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE 420 430 440 450 460 470 160 170 180 190 200 210 fh0404 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES 480 490 500 510 520 530 220 230 240 250 260 270 fh0404 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: gi|168 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQPPRKAG 540 550 560 570 580 590 280 290 300 310 320 330 fh0404 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 600 610 620 630 640 650 340 350 360 370 380 390 fh0404 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 660 670 680 690 700 710 400 410 420 430 440 450 fh0404 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 720 730 740 750 760 770 460 470 480 490 500 510 fh0404 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|168 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQAKPSGKTHQIRAALAPAKESPRKG 780 790 800 810 820 830 520 530 540 550 560 570 fh0404 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 840 850 860 870 880 890 580 590 600 610 620 630 fh0404 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 900 910 920 930 940 950 640 650 660 670 680 690 fh0404 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP 960 970 980 990 1000 1010 700 710 fh0404 VARTQPSSGVSLGSQGKQAHGA :::::::::: gi|168 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1020 1030 1040 1050 1060 1070 >>gi|1778432|gb|AAB40722.1| Treacher Collins syndrome [H (1411 aa) initn: 4424 init1: 4424 opt: 4424 Z-score: 3283.1 bits: 619.0 E(): 3.2e-174 Smith-Waterman score: 4424; 99.714% identity (99.857% similar) in 700 aa overlap (1-700:324-1023) 10 20 30 fh0404 AQAGKREEDSQSSSEESDSEEEAPAQAKPS :::::::::::::::::::::::::::::: gi|177 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 300 310 320 330 340 350 40 50 60 70 80 90 fh0404 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|177 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA 360 370 380 390 400 410 100 110 120 130 140 150 fh0404 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|177 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE 420 430 440 450 460 470 160 170 180 190 200 210 fh0404 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|177 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES 480 490 500 510 520 530 220 230 240 250 260 270 fh0404 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: gi|177 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQPPRKAG 540 550 560 570 580 590 280 290 300 310 320 330 fh0404 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|177 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 600 610 620 630 640 650 340 350 360 370 380 390 fh0404 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|177 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 660 670 680 690 700 710 400 410 420 430 440 450 fh0404 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|177 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 720 730 740 750 760 770 460 470 480 490 500 510 fh0404 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|177 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQAKPSGKTHQIRAALAPAKESPRKG 780 790 800 810 820 830 520 530 540 550 560 570 fh0404 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|177 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 840 850 860 870 880 890 580 590 600 610 620 630 fh0404 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|177 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 900 910 920 930 940 950 640 650 660 670 680 690 fh0404 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|177 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP 960 970 980 990 1000 1010 700 710 fh0404 VARTQPSSGVSLGSQGKQAHGA :::::::::: gi|177 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1020 1030 1040 1050 1060 1070 >>gi|122066350|sp|Q13428|TCOF_HUMAN Treacle protein (Tre (1488 aa) initn: 4424 init1: 4424 opt: 4424 Z-score: 3282.8 bits: 619.0 E(): 3.3e-174 Smith-Waterman score: 4424; 99.714% identity (99.857% similar) in 700 aa overlap (1-700:401-1100) 10 20 30 fh0404 AQAGKREEDSQSSSEESDSEEEAPAQAKPS :::::::::::::::::::::::::::::: gi|122 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 380 390 400 410 420 430 40 50 60 70 80 90 fh0404 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA 440 450 460 470 480 490 100 110 120 130 140 150 fh0404 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE 500 510 520 530 540 550 160 170 180 190 200 210 fh0404 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES 560 570 580 590 600 610 220 230 240 250 260 270 fh0404 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: gi|122 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQPPRKAG 620 630 640 650 660 670 280 290 300 310 320 330 fh0404 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 680 690 700 710 720 730 340 350 360 370 380 390 fh0404 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 740 750 760 770 780 790 400 410 420 430 440 450 fh0404 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 800 810 820 830 840 850 460 470 480 490 500 510 fh0404 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|122 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQAKPSGKTHQIRAALAPAKESPRKG 860 870 880 890 900 910 520 530 540 550 560 570 fh0404 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 920 930 940 950 960 970 580 590 600 610 620 630 fh0404 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 980 990 1000 1010 1020 1030 640 650 660 670 680 690 fh0404 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP 1040 1050 1060 1070 1080 1090 700 710 fh0404 VARTQPSSGVSLGSQGKQAHGA :::::::::: gi|122 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1100 1110 1120 1130 1140 1150 >>gi|114602823|ref|XP_527074.2| PREDICTED: Treacher Coll (1411 aa) initn: 4214 init1: 4214 opt: 4214 Z-score: 3127.6 bits: 590.2 E(): 1.4e-165 Smith-Waterman score: 4214; 95.000% identity (98.429% similar) in 700 aa overlap (1-700:324-1023) 10 20 30 fh0404 AQAGKREEDSQSSSEESDSEEEAPAQAKPS :::::::::::::::::::::::::::::: gi|114 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 300 310 320 330 340 350 40 50 60 70 80 90 fh0404 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA ::::::::::::::::::::.:::::::::::::::::::::::: :::::::::::::: gi|114 GKAPQVRAASAPAKESPRKGTAPAPPRKTGPAAAQVQVGKQEEDSGSSSEESDSDREALA 360 370 380 390 400 410 100 110 120 130 140 150 fh0404 AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 AMNAAXVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE 420 430 440 450 460 470 160 170 180 190 200 210 fh0404 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES ::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::: gi|114 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPASSPAKGPPQKAGPVAVQVKAEKPMDNSES 480 490 500 510 520 530 220 230 240 250 260 270 fh0404 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: gi|114 SEESSDSADSEEAPAVMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG 540 550 560 570 580 590 280 290 300 310 320 330 fh0404 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 600 610 620 630 640 650 340 350 360 370 380 390 fh0404 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 660 670 680 690 700 710 400 410 420 430 440 450 fh0404 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: gi|114 KANPAAARAPSAKGTISAPGKVVTAAAQVKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 720 730 740 750 760 770 460 470 480 490 500 510 fh0404 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG ::::::::.:::::::::::::::::::::.:::::.:::::: :::::::::::::::: gi|114 GKAVATAARAQTGPEEDSGSSEEESDSEEEVETLAQAKPSGKTPQIRAALAPAKESPRKG 780 790 800 810 820 830 520 530 540 550 560 570 fh0404 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG ::::::::::::: .. :.:.:: .. ...: ...:: .: .::::::::::::::::: gi|114 AAPTPPGKTGPSALEGWKHDSSGCGAGQASSLSHSPAQATPPRVIKPPLIFVDPNRSPAG 840 850 860 870 880 890 580 590 600 610 620 630 fh0404 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: gi|114 PAATPAQAQAASTPRKGRASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 900 910 920 930 940 950 640 650 660 670 680 690 fh0404 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|114 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQATLKVLAQKASEAQPP 960 970 980 990 1000 1010 700 710 fh0404 VARTQPSSGVSLGSQGKQAHGA :::::::::: gi|114 VARTQPSSGVDSAVGTLPATSPQSSSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1020 1030 1040 1050 1060 1070 712 residues in 1 query sequences 2355815254 residues in 6825066 library sequences Tcomplib [34.26] (8 proc) start: Sat Aug 9 12:20:26 2008 done: Sat Aug 9 12:22:26 2008 Total Scan time: 973.820 Total Display time: 0.390 Function used was FASTA [version 34.26.5 April 26, 2007]