# /hgtech/tools/solaris8/bin/fasta34_t -T 8 -b50 -d10 -E0.01 -H -Ofh16154.fasta.nr -Q fh16154.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 fh16154, 533 aa vs /cdna2/lib/nr/nr library 2355815254 residues in 6825066 sequences statistics sampled from 60000 to 6808290 sequences Expectation_n fit: rho(ln(x))= 5.9265+/-0.000204; mu= 9.1405+/- 0.011 mean_var=127.0837+/-24.505, 0's: 38 Z-trim: 89 B-trim: 433 in 1/66 Lambda= 0.113770 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 37, opt: 25, open/ext: -10/-2, width: 16 The best scores are: opt bits E(6825066) gi|62088298|dbj|BAD92596.1| cholinergic receptor, ( 533) 3726 622.9 5.9e-176 gi|64653281|gb|AAH96291.1| CHRNA4 protein [Homo sa ( 556) 3495 585.0 1.6e-164 gi|119595675|gb|EAW75269.1| cholinergic receptor, ( 546) 3467 580.4 3.8e-163 gi|854159|emb|CAA60959.1| nicotinic acetylcholine ( 602) 3467 580.5 4e-163 gi|64654852|gb|AAH96290.1| Cholinergic receptor, n ( 627) 3467 580.5 4.1e-163 gi|1351848|sp|P43681|ACHA4_HUMAN Neuronal acetylch ( 627) 3467 580.5 4.1e-163 gi|61211735|sp|Q5IS77|ACHA4_PANTR Neuronal acetylc ( 627) 3394 568.5 1.7e-159 gi|109091349|ref|XP_001114265.1| PREDICTED: cholin ( 659) 3272 548.5 1.8e-153 gi|64653285|gb|AAH96293.1| CHRNA4 protein [Homo sa ( 451) 3115 522.5 8.2e-146 gi|194238319|ref|XP_001914996.1| PREDICTED: simila ( 520) 2923 491.1 2.8e-136 gi|56122198|gb|AAV74250.1| cholinergic receptor ne ( 537) 2842 477.8 2.8e-132 gi|148675426|gb|EDL07373.1| cholinergic receptor, ( 629) 2818 474.0 4.8e-131 gi|34978348|sp|O70174|ACHA4_MOUSE Neuronal acetylc ( 629) 2818 474.0 4.8e-131 gi|9886085|gb|AAF34716.2|AF225912_1 nicotinic acet ( 629) 2812 473.0 9.6e-131 gi|149033985|gb|EDL88768.1| cholinergic receptor, ( 630) 2802 471.3 3e-130 gi|205640|gb|AAA41676.1| acetylcholine receptor al ( 626) 2797 470.5 5.3e-130 gi|2253413|gb|AAB64439.1| nicotinic acetylcholine ( 630) 2797 470.5 5.3e-130 gi|4028904|gb|AAC97071.1| nicotinic acetylcholine ( 629) 2782 468.0 2.9e-129 gi|149033986|gb|EDL88769.1| cholinergic receptor, ( 629) 2782 468.0 2.9e-129 gi|92550|pir||A26456 nicotinic acetylcholine recep ( 625) 2777 467.2 5.1e-129 gi|122142601|sp|Q19AE6.1|ACHA4_MUSPF Neuronal acet ( 627) 2774 466.7 7.2e-129 gi|8469182|sp|P09483|ACHA4_RAT Neuronal acetylchol ( 630) 2770 466.1 1.1e-128 gi|126303021|ref|XP_001376203.1| PREDICTED: simila ( 631) 2536 427.7 4.2e-117 gi|149636046|ref|XP_001506577.1| PREDICTED: simila ( 624) 2509 423.2 8.9e-116 gi|113062|sp|P09482|ACHA4_CHICK Neuronal acetylcho ( 622) 2461 415.4 2.1e-113 gi|73992736|ref|XP_543097.2| PREDICTED: similar to ( 681) 2343 396.0 1.5e-107 gi|161611545|gb|AAI55717.1| Unknown (protein for M ( 734) 2287 386.9 9.3e-105 gi|149033987|gb|EDL88770.1| cholinergic receptor, ( 450) 2072 351.4 2.8e-94 gi|110748668|gb|ABG89874.1| neuronal nicotinic ace ( 627) 1871 318.5 3e-84 gi|119905611|ref|XP_617408.3| PREDICTED: similar t ( 592) 1786 304.5 4.6e-80 gi|5763787|emb|CAB53250.1| nicotinic acetylcholine ( 259) 1587 271.5 1.8e-70 gi|17225360|gb|AAL37363.1|AF325347_1 nicotinic ace ( 240) 1518 260.1 4.3e-67 gi|31790081|gb|AAP58377.1| nicotinic acetylcholine ( 622) 1503 258.1 4.5e-66 gi|47212225|emb|CAF91943.1| unnamed protein produc ( 610) 1485 255.1 3.5e-65 gi|55962651|emb|CAI11602.1| novel cholinergic rece ( 526) 1392 239.8 1.2e-60 gi|189533063|ref|XP_697298.2| PREDICTED: cholinerg ( 536) 1392 239.8 1.2e-60 gi|31790074|gb|AAP58375.1| nicotinic acetylcholine ( 439) 1381 237.9 3.8e-60 gi|92098271|gb|AAI15238.1| Zgc:136717 [Danio rerio ( 520) 1381 238.0 4.3e-60 gi|119583956|gb|EAW63552.1| cholinergic receptor, ( 529) 1377 237.4 6.8e-60 gi|158253953|gb|AAI53867.1| Cholinergic receptor, ( 529) 1377 237.4 6.8e-60 gi|2492619|sp|Q15822|ACHA2_HUMAN Neuronal acetylch ( 529) 1377 237.4 6.8e-60 gi|56122236|gb|AAV74269.1| cholinergic receptor ne ( 514) 1375 237.0 8.4e-60 gi|190338024|gb|AAI62563.1| Zgc:136717 [Danio reri ( 520) 1375 237.0 8.5e-60 gi|113053|sp|P09480|ACHA2_CHICK Neuronal acetylcho ( 528) 1375 237.0 8.6e-60 gi|109085980|ref|XP_001109335.1| PREDICTED: cholin ( 529) 1374 236.9 9.6e-60 gi|61211728|sp|Q5IS52|ACHA2_PANTR Neuronal acetylc ( 529) 1374 236.9 9.6e-60 gi|73993952|ref|XP_543227.2| PREDICTED: similar to ( 490) 1370 236.2 1.4e-59 gi|30144567|gb|AAP14897.1| nicotinic acetylcholine ( 520) 1370 236.2 1.5e-59 gi|149746426|ref|XP_001492704.1| PREDICTED: simila ( 630) 1364 235.3 3.4e-59 gi|202674|gb|AAA40664.1| nicotinic acetylcholine r ( 511) 1359 234.4 5.2e-59 >>gi|62088298|dbj|BAD92596.1| cholinergic receptor, nico (533 aa) initn: 3726 init1: 3726 opt: 3726 Z-score: 3314.1 bits: 622.9 E(): 5.9e-176 Smith-Waterman score: 3726; 100.000% identity (100.000% similar) in 533 aa overlap (1-533:1-533) 10 20 30 40 50 60 fh1615 APEPGEAPRLDRAHPGCACAELSLLWLCCCTFTSADGDFAVTHLTKAHLFHDGRVQWTPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 APEPGEAPRLDRAHPGCACAELSLLWLCCCTFTSADGDFAVTHLTKAHLFHDGRVQWTPP 10 20 30 40 50 60 70 80 90 100 110 120 fh1615 AIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 AIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDA 70 80 90 100 110 120 130 140 150 160 170 180 fh1615 VGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 VGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEK 130 140 150 160 170 180 190 200 210 220 230 240 fh1615 ITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 ITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRS 190 200 210 220 230 240 250 260 270 280 290 300 fh1615 PRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 PRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPA 250 260 270 280 290 300 310 320 330 340 350 360 fh1615 TSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 TSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHG 310 320 330 340 350 360 370 380 390 400 410 420 fh1615 TQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 TQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRN 370 380 390 400 410 420 430 440 450 460 470 480 fh1615 THSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 THSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYI 430 440 450 460 470 480 490 500 510 520 530 fh1615 ADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI ::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 ADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI 490 500 510 520 530 >>gi|64653281|gb|AAH96291.1| CHRNA4 protein [Homo sapien (556 aa) initn: 3462 init1: 3462 opt: 3495 Z-score: 3109.0 bits: 585.0 E(): 1.6e-164 Smith-Waterman score: 3495; 96.743% identity (97.510% similar) in 522 aa overlap (12-533:38-556) 10 20 30 40 fh1615 APEPGEAPRLDRAHPGCACAELSLLWLCCCTFTSADGDFAV : ::: . ..: : .::::::: gi|646 ASPPSSSGGRTSSSTTTAGEPFWAGVLFAIRPHPGLSG---RIVWTAGCPGEGADGDFAV 10 20 30 40 50 60 50 60 70 80 90 100 fh1615 THLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 THLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMH 70 80 90 100 110 120 110 120 130 140 150 160 fh1615 SRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 SRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCL 130 140 150 160 170 180 170 180 190 200 210 220 fh1615 LISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 LISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMI 190 200 210 220 230 240 230 240 250 260 270 280 fh1615 FVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 FVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESM 250 260 270 280 290 300 290 300 310 320 330 340 fh1615 HKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 HKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPL 310 320 330 340 350 360 350 360 370 380 390 400 fh1615 EAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 EAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPR 370 380 390 400 410 420 410 420 430 440 450 460 fh1615 DDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 DDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPP 430 440 450 460 470 480 470 480 490 500 510 520 fh1615 PHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 PHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTV 490 500 510 520 530 540 530 fh1615 GLFLPPWLAGMI :::::::::::: gi|646 GLFLPPWLAGMI 550 >>gi|119595675|gb|EAW75269.1| cholinergic receptor, nico (546 aa) initn: 3467 init1: 3467 opt: 3467 Z-score: 3084.2 bits: 580.4 E(): 3.8e-163 Smith-Waterman score: 3467; 99.402% identity (100.000% similar) in 502 aa overlap (32-533:45-546) 10 20 30 40 50 60 fh1615 PEPGEAPRLDRAHPGCACAELSLLWLCCCTFTSADGDFAVTHLTKAHLFHDGRVQWTPPA ...::::::::::::::::::::::::::: gi|119 YKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPA 20 30 40 50 60 70 70 80 90 100 110 120 fh1615 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV 80 90 100 110 120 130 130 140 150 160 170 180 fh1615 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI 140 150 160 170 180 190 190 200 210 220 230 240 fh1615 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP 200 210 220 230 240 250 250 260 270 280 290 300 fh1615 RTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPAT 260 270 280 290 300 310 310 320 330 340 350 360 fh1615 SGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGT 320 330 340 350 360 370 370 380 390 400 410 420 fh1615 QAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 QAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNT 380 390 400 410 420 430 430 440 450 460 470 480 fh1615 HSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 HSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIA 440 450 460 470 480 490 490 500 510 520 530 fh1615 DHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI :::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI 500 510 520 530 540 >>gi|854159|emb|CAA60959.1| nicotinic acetylcholine rece (602 aa) initn: 3467 init1: 3467 opt: 3467 Z-score: 3083.7 bits: 580.5 E(): 4e-163 Smith-Waterman score: 3467; 99.402% identity (100.000% similar) in 502 aa overlap (32-533:101-602) 10 20 30 40 50 60 fh1615 PEPGEAPRLDRAHPGCACAELSLLWLCCCTFTSADGDFAVTHLTKAHLFHDGRVQWTPPA ...::::::::::::::::::::::::::: gi|854 YKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPA 80 90 100 110 120 130 70 80 90 100 110 120 fh1615 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|854 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV 140 150 160 170 180 190 130 140 150 160 170 180 fh1615 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|854 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI 200 210 220 230 240 250 190 200 210 220 230 240 fh1615 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|854 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP 260 270 280 290 300 310 250 260 270 280 290 300 fh1615 RTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|854 RTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPAT 320 330 340 350 360 370 310 320 330 340 350 360 fh1615 SGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|854 SGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGT 380 390 400 410 420 430 370 380 390 400 410 420 fh1615 QAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|854 QAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNT 440 450 460 470 480 490 430 440 450 460 470 480 fh1615 HSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|854 HSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIA 500 510 520 530 540 550 490 500 510 520 530 fh1615 DHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI :::::::::::::::::::::::::::::::::::::::::::::::::::: gi|854 DHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI 560 570 580 590 600 >>gi|64654852|gb|AAH96290.1| Cholinergic receptor, nicot (627 aa) initn: 3467 init1: 3467 opt: 3467 Z-score: 3083.5 bits: 580.5 E(): 4.1e-163 Smith-Waterman score: 3467; 99.402% identity (100.000% similar) in 502 aa overlap (32-533:126-627) 10 20 30 40 50 60 fh1615 PEPGEAPRLDRAHPGCACAELSLLWLCCCTFTSADGDFAVTHLTKAHLFHDGRVQWTPPA ...::::::::::::::::::::::::::: gi|646 YKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPA 100 110 120 130 140 150 70 80 90 100 110 120 fh1615 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV 160 170 180 190 200 210 130 140 150 160 170 180 fh1615 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI 220 230 240 250 260 270 190 200 210 220 230 240 fh1615 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP 280 290 300 310 320 330 250 260 270 280 290 300 fh1615 RTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 RTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPAT 340 350 360 370 380 390 310 320 330 340 350 360 fh1615 SGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 SGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGT 400 410 420 430 440 450 370 380 390 400 410 420 fh1615 QAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 QAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNT 460 470 480 490 500 510 430 440 450 460 470 480 fh1615 HSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 HSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIA 520 530 540 550 560 570 490 500 510 520 530 fh1615 DHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI :::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 DHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI 580 590 600 610 620 >>gi|1351848|sp|P43681|ACHA4_HUMAN Neuronal acetylcholin (627 aa) initn: 3467 init1: 3467 opt: 3467 Z-score: 3083.5 bits: 580.5 E(): 4.1e-163 Smith-Waterman score: 3467; 99.402% identity (100.000% similar) in 502 aa overlap (32-533:126-627) 10 20 30 40 50 60 fh1615 PEPGEAPRLDRAHPGCACAELSLLWLCCCTFTSADGDFAVTHLTKAHLFHDGRVQWTPPA ...::::::::::::::::::::::::::: gi|135 YKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPA 100 110 120 130 140 150 70 80 90 100 110 120 fh1615 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|135 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV 160 170 180 190 200 210 130 140 150 160 170 180 fh1615 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|135 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI 220 230 240 250 260 270 190 200 210 220 230 240 fh1615 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|135 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP 280 290 300 310 320 330 250 260 270 280 290 300 fh1615 RTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|135 RTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPAT 340 350 360 370 380 390 310 320 330 340 350 360 fh1615 SGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|135 SGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGT 400 410 420 430 440 450 370 380 390 400 410 420 fh1615 QAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|135 QAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNT 460 470 480 490 500 510 430 440 450 460 470 480 fh1615 HSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|135 HSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIA 520 530 540 550 560 570 490 500 510 520 530 fh1615 DHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI :::::::::::::::::::::::::::::::::::::::::::::::::::: gi|135 DHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI 580 590 600 610 620 >>gi|61211735|sp|Q5IS77|ACHA4_PANTR Neuronal acetylcholi (627 aa) initn: 3394 init1: 3394 opt: 3394 Z-score: 3018.7 bits: 568.5 E(): 1.7e-159 Smith-Waterman score: 3394; 97.410% identity (99.004% similar) in 502 aa overlap (32-533:126-627) 10 20 30 40 50 60 fh1615 PEPGEAPRLDRAHPGCACAELSLLWLCCCTFTSADGDFAVTHLTKAHLFHDGRVQWTPPA ...::::::::::::::::::::::::::: gi|612 YKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPA 100 110 120 130 140 150 70 80 90 100 110 120 fh1615 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|612 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV 160 170 180 190 200 210 130 140 150 160 170 180 fh1615 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|612 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI 220 230 240 250 260 270 190 200 210 220 230 240 fh1615 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|612 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP 280 290 300 310 320 330 250 260 270 280 290 300 fh1615 RTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|612 RTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPAT 340 350 360 370 380 390 310 320 330 340 350 360 fh1615 SGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGT ::::::::::::::.:::::::::::::::::::: :::::::::::: ::::::::::: gi|612 SGTQSLHPPSPSFCIPLDVPAEPGPSCKSPSDQLPAQQPLEAEKASPHASPGPCRPPHGT 400 410 420 430 440 450 370 380 390 400 410 420 fh1615 QAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNT ::::::::::::::::::::::::::.::::::::::::::::. :: :::::::::::: gi|612 QAPGLAKARSLSVQHMSSPGEAVEGGIRCRSRSIQYCVPRDDATSEAGGQAAGALASRNT 460 470 480 490 500 510 430 440 450 460 470 480 fh1615 HSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIA :::::::::.::::::::::::::::::::::.::::::: ::::::::::::::::::: gi|612 HSAELPPPDRPSPCKCTCKKEPSSVSPSATVKARSTKAPPRHLPLSPALTRAVEGVQYIA 520 530 540 550 560 570 490 500 510 520 530 fh1615 DHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI :::::::::::::::::::::::::::::::::::::::::::::::::::: gi|612 DHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI 580 590 600 610 620 >>gi|109091349|ref|XP_001114265.1| PREDICTED: cholinergi (659 aa) initn: 1917 init1: 1885 opt: 3272 Z-score: 2910.2 bits: 548.5 E(): 1.8e-153 Smith-Waterman score: 3272; 95.219% identity (97.410% similar) in 502 aa overlap (32-533:159-659) 10 20 30 40 50 60 fh1615 PEPGEAPRLDRAHPGCACAELSLLWLCCCTFTSADGDFAVTHLTKAHLFHDGRVQWTPPA ...::::::::::::::::::::::::::: gi|109 YKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPA 130 140 150 160 170 180 70 80 90 100 110 120 fh1615 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV 190 200 210 220 230 240 130 140 150 160 170 180 fh1615 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI 250 260 270 280 290 300 190 200 210 220 230 240 fh1615 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP 310 320 330 340 350 360 250 260 270 280 290 300 fh1615 RTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPAT ::::::.:::::::::::::::::::::::::::::::::::::::::::::::::: :: gi|109 RTHTMPAWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPAAT 370 380 390 400 410 420 310 320 330 340 350 360 fh1615 SGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGT ::::: :::::: ::::::::: ::.::::::::: :: ::::::::::::: ::::.: gi|109 SGTQSRHPPSPS-CVPLDVPAESGPACKSPSDQLPALQPPEAEKASPHPSPGPYRPPHST 430 440 450 460 470 480 370 380 390 400 410 420 fh1615 QAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNT :::::::::::::::::::::::::::::::::::::::::.:::::: :::::::::.: gi|109 QAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDNAAPEADVQAAGALASRKT 490 500 510 520 530 540 430 440 450 460 470 480 fh1615 HSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIA ::::::::::::: :::: ::: :::::::.:.::::::: ::::::::::::::::::: gi|109 HSAELPPPDQPSPRKCTCGKEPPSVSPSATLKARSTKAPPRHLPLSPALTRAVEGVQYIA 550 560 570 580 590 600 490 500 510 520 530 fh1615 DHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI :::::::.:::::::::::::::::::::::::::::::::::::::::::: gi|109 DHLKAEDADFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI 610 620 630 640 650 >>gi|64653285|gb|AAH96293.1| CHRNA4 protein [Homo sapien (451 aa) initn: 3115 init1: 3115 opt: 3115 Z-score: 2773.0 bits: 522.5 E(): 8.2e-146 Smith-Waterman score: 3115; 100.000% identity (100.000% similar) in 451 aa overlap (83-533:1-451) 60 70 80 90 100 110 fh1615 GRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWES :::::::::::::::::::::::::::::: gi|646 MKFGSWTYDKAKIDLVNMHSRVDQLDFWES 10 20 30 120 130 140 150 160 170 fh1615 GEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 GEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFY 40 50 60 70 80 90 180 190 200 210 220 230 fh1615 LPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 LPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF 100 110 120 130 140 150 240 250 260 270 280 290 fh1615 VLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 VLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWP 160 170 180 190 200 210 300 310 320 330 340 350 fh1615 EPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 EPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSP 220 230 240 250 260 270 360 370 380 390 400 410 fh1615 GPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 GPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQA 280 290 300 310 320 330 420 430 440 450 460 470 fh1615 AGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 AGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTR 340 350 360 370 380 390 480 490 500 510 520 530 fh1615 AVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|646 AVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGM 400 410 420 430 440 450 fh1615 I : gi|646 I >>gi|194238319|ref|XP_001914996.1| PREDICTED: similar to (520 aa) initn: 2580 init1: 1753 opt: 2923 Z-score: 2601.9 bits: 491.1 E(): 2.8e-136 Smith-Waterman score: 2923; 84.950% identity (93.267% similar) in 505 aa overlap (32-533:17-520) 10 20 30 40 50 60 fh1615 PEPGEAPRLDRAHPGCACAELSLLWLCCCTFTSADGDFAVTHLTKAHLFHDGRVQWTPPA ...::::::::::::::::::::::::::: gi|194 SIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPA 10 20 30 40 70 80 90 100 110 120 fh1615 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAV :::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::: gi|194 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAV 50 60 70 80 90 100 130 140 150 160 170 180 fh1615 GTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI :::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::: gi|194 GTYNTRKYECCAEVYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKI 110 120 130 140 150 160 190 200 210 220 230 240 fh1615 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: gi|194 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSP 170 180 190 200 210 220 250 260 270 280 290 fh1615 RTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPE--GEPP ::::::.::::::::::::::.:::::::::::::::::::::::.:: ::::: ::: gi|194 RTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMASTPRVWPEPEPEGEPN 230 240 250 260 270 280 300 310 320 330 340 350 fh1615 ATSGTQSLHP-PSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPP .::.:: : :.:::: ::: ..: :.:::::::.: :: :.:::: :: .: .:: gi|194 FVSGVQSQGPSPTPSFCGPLDETVKPQPACKSPSDQVPTLQPSETEKASACPSLAPGHPP 290 300 310 320 330 340 360 370 380 390 400 410 fh1615 HGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALAS ::.:::.::::::::::::::..: ::::::::.:::: :::: :: ::. ::.. .: gi|194 TGTRAPGIAKARSLSVQHMSSPSKA-EGGVRCRSQSIQYSVPRDAAASEAEDPAASSSTS 350 360 370 380 390 400 420 430 440 450 460 470 fh1615 RNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQ .. :.::::::: ::::: :::::. ::....:.::::.:: :.::::.::::::::: gi|194 LKAPSTELPPPDQASPCKCKCKKEPALESPNTALKARSTKGPPRHVPLSPVLTRAVEGVQ 410 420 430 440 450 460 480 490 500 510 520 530 fh1615 YIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI ::::::::::::::::::::::::::::::::.:::::::::.:::::::::::: gi|194 YIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWVFIIVCLLGTAGLFLPPWLAGMI 470 480 490 500 510 520 533 residues in 1 query sequences 2355815254 residues in 6825066 library sequences Tcomplib [34.26] (8 proc) start: Sat Aug 9 19:23:21 2008 done: Sat Aug 9 19:25:41 2008 Total Scan time: 890.690 Total Display time: 0.170 Function used was FASTA [version 34.26.5 April 26, 2007]