hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080812/iprscan-20080812-00433199/chunk_1/iprscan-20080812-00433199.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: hg00295 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF07679.6.ls Immunoglobulin I-set domain 970.3 6.9e-289 9 PF07679.6.fs Immunoglobulin I-set domain 952.9 1.2e-283 9 PF00069.15.ls Protein kinase domain 353.9 2.4e-103 1 PF00069.15.fs Protein kinase domain 352.0 8.9e-103 1 PF00047.15.ls Immunoglobulin domain 301.7 1.3e-87 9 PF00047.15.fs Immunoglobulin domain 291.2 1.8e-84 9 PF07686.7.ls Immunoglobulin V-set domain 138.3 1.9e-38 9 PF07686.7.fs Immunoglobulin V-set domain 128.4 1.2e-35 9 PF00041.11.fs Fibronectin type III domain 80.1 2.3e-22 1 PF00041.11.ls Fibronectin type III domain 82.1 1.6e-21 1 PF07714.7.fs Protein tyrosine kinase 37.9 6.7e-11 1 PF08205.3.fs CD80-like C2-set immunoglobulin domain 36.4 1.1e-09 6 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF07679.6.fs 1/9 140 230 .. 1 96 [] 116.1 2.9e-33 PF07686.7.ls 1/9 140 227 .. 1 141 [] 13.9 0.002 PF07679.6.ls 1/9 140 230 .. 1 96 [] 118.1 2.4e-32 PF00047.15.ls 1/9 154 215 .. 1 65 [] 28.6 2e-05 PF00047.15.fs 1/9 154 215 .. 1 65 [] 26.7 1.4e-06 PF07686.7.ls 2/9 253 379 .. 1 141 [] 20.4 0.00043 PF07686.7.fs 2/9 253 379 .. 1 141 [] 18.7 8.1e-05 PF07679.6.fs 2/9 268 357 .. 1 96 [] 121.3 8.9e-35 PF07679.6.ls 2/9 268 357 .. 1 96 [] 123.3 6.5e-34 PF00047.15.fs 2/9 282 342 .. 1 65 [] 38.4 9e-10 PF00047.15.ls 2/9 282 342 .. 1 65 [] 40.3 6.3e-09 PF07686.7.ls 3/9 456 612 .. 1 141 [] 12.7 0.0026 PF07679.6.fs 3/9 521 611 .. 1 96 [] 102.3 3.1e-29 PF07679.6.ls 3/9 521 611 .. 1 96 [] 104.2 3.4e-28 PF00047.15.fs 3/9 535 596 .. 1 65 [] 33.5 1.9e-08 PF00047.15.ls 3/9 535 596 .. 1 65 [] 35.4 1.8e-07 PF07679.6.ls 4/9 621 707 .. 1 96 [] 96.8 6e-26 PF07679.6.fs 4/9 621 707 .. 1 96 [] 94.9 4.5e-27 PF07686.7.ls 4/9 623 708 .. 1 141 [] 14.1 0.0019 PF00047.15.ls 4/9 635 692 .. 1 65 [] 43.6 6e-10 PF00047.15.fs 4/9 635 692 .. 1 65 [] 41.8 1e-10 PF07686.7.fs 5/9 730 820 .. 1 141 [] 21.2 1.6e-05 PF07686.7.ls 5/9 730 820 .. 1 141 [] 22.9 0.00024 PF07679.6.fs 5/9 730 819 .. 1 96 [] 113.7 1.5e-32 PF07679.6.ls 5/9 730 819 .. 1 96 [] 115.6 1.3e-31 PF00047.15.fs 5/9 744 804 .. 1 65 [] 45.5 1e-11 PF00047.15.ls 5/9 744 804 .. 1 65 [] 47.4 4.6e-11 PF07686.7.fs 6/9 828 893 .. 1 114 [. 20.6 2.4e-05 PF07679.6.ls 6/9 828 918 .. 1 96 [] 74.4 3.4e-19 PF07679.6.fs 6/9 828 918 .. 1 96 [] 72.4 1.6e-20 PF07686.7.ls 6/9 828 919 .. 1 141 [] 18.7 0.00064 PF00047.15.fs 6/9 842 899 .. 1 61 [. 25.5 3e-06 PF00047.15.ls 6/9 842 903 .. 1 65 [] 22.4 0.0016 PF07686.7.ls 7/9 1205 1295 .. 1 141 [] 13.8 0.002 PF07679.6.ls 7/9 1205 1294 .. 1 96 [] 93.8 4.7e-25 PF07679.6.fs 7/9 1205 1294 .. 1 96 [] 91.9 3.4e-26 PF00047.15.ls 7/9 1219 1279 .. 1 65 [] 40.0 7.6e-09 PF00047.15.fs 7/9 1219 1279 .. 1 65 [] 38.1 1.1e-09 PF07686.7.ls 8/9 1344 1435 .. 1 141 [] 13.1 0.0023 PF07679.6.ls 8/9 1345 1434 .. 1 96 [] 76.4 8.3e-20 PF07679.6.fs 8/9 1345 1434 .. 1 96 [] 74.5 4.1e-21 PF00041.11.fs 1/1 1438 1523 .. 1 84 [] 80.1 2.3e-22 PF00041.11.ls 1/1 1438 1523 .. 1 84 [] 82.1 1.6e-21 PF00069.15.ls 1/1 1571 1826 .. 1 287 [] 353.9 2.4e-103 PF00069.15.fs 1/1 1571 1826 .. 1 287 [] 352.0 8.9e-103 PF07714.7.fs 1/1 1571 1693 .. 1 139 [. 37.9 6.7e-11 PF07679.6.ls 9/9 1915 2005 .. 1 96 [] 167.7 2.8e-47 PF07679.6.fs 9/9 1915 2005 .. 1 96 [] 165.7 1e-47 PF00047.15.fs 9/9 1929 1990 .. 1 65 [] 32.2 4.3e-08 PF00047.15.ls 9/9 1929 1990 .. 1 65 [] 34.1 4.4e-07 Alignments of top-scoring domains: PF07679.6.fs: domain 1 of 9, from 140 to 230: score 116.1, E = 2.9e-33 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P F+ +p+++ ++eG +a+fe +V+G+PeP+V+W+++Gqp++s hg00295 140 PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITS---- 182 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< ++rf ++ +gt +L+I v +D GkYtC AtN +G ++++eLtV hg00295 183 GGRFLLDCGI-RGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTV 230 -* hg00295 - - PF07686.7.ls: domain 1 of 9, from 140 to 227: score 13.9, E = 0.002 *->qsqvtqepprWGLLLASLfWptsvtvaeGgsvtLpCtysGtfddsss + + + pr + +eG+++++ ++ ++ hg00295 140 PAFILP--PR------------NLCIKEGATAKFEGRVR----GY-- 166 ssgtfsiyWyrq.qppgkgpeliiisyysyystsegngtvgerfkgrvtl ++ +++W r++qp +g ++l hg00295 167 --PEPQVTWHRNgQPI---------------------------TSGGRFL 187 sgnpskgdfsLtIsnlqlsDsGtYyCavsnsnelvfgggtrLtVl<-* ++ +g+fsL I+ ++ +D G Y+C n g ++tV+ hg00295 188 LDCGIRGTFSLVIHAVHEEDRGKYTCEATN-----GSGARQVTVE 227 PF07679.6.ls: domain 1 of 9, from 140 to 230: score 118.1, E = 2.4e-32 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P F+ +p+++ ++eG +a+fe +V+G+PeP+V+W+++Gqp++s hg00295 140 PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITS---- 182 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< ++rf ++ +gt +L+I v +D GkYtC AtN +G ++++eLtV hg00295 183 GGRFLLDCGI-RGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTV 230 -* hg00295 - - PF00047.15.ls: domain 1 of 9, from 154 to 215: score 28.6, E = 2e-05 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G ++++ +v g p+++vtW+rng+++t+g + + + ++ hg00295 154 GATAKFEGRV--RGYPEPQVTWHRNGQpITsGGRFLLDCGIRGTFS- 197 tsLtitnvtpeDggtYtCvv<-* L+i++v +eD g YtC++ hg00295 198 --LVIHAVHEEDRGKYTCEA 215 PF00047.15.fs: domain 1 of 9, from 154 to 215: score 26.7, E = 1.4e-06 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G ++++ +v g p+++vtW+rng+++t+g + + + ++ hg00295 154 GATAKFEGRV--RGYPEPQVTWHRNGQpITsGGRFLLDCGIRGTFS- 197 tsLtitnvtpeDggtYtCvv<-* L+i++v +eD g YtC++ hg00295 198 --LVIHAVHEEDRGKYTCEA 215 PF07686.7.ls: domain 2 of 9, from 253 to 379: score 20.4, E = 0.00043 *->qsqvtqepprWGLLLASLfW.p.t........svtvaeGgsvtLpCt +s v++ p+ +W+ +++ ++ + v+v+eG++ +++C+ hg00295 253 ASAVET-RPS--------IWgEcPpkfatklgRVVVKEGQMGRFSCK 290 ysGtfddsssssgtfsiyWyrqqppgkgpeliiisyysyystsegngtvg + + + ++ +++W + ++ hg00295 291 IT---GRP----QP-QVTWLK-GNV------------------------- 306 erfkgrvtlsgnpskgdfsLtIsnlqlsDsGtYyCavsns.......... +++ + ++s++ +g L I+ + ++D G+Y+C v n++++ + + + hg00295 307 -PLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGsgkasmsael 355 ..........nelvfgggtrLtVl<-* + ++ ++ +++++ + t+ V+ hg00295 356 siqgldsanrSFVRETKATNSDVR 379 PF07686.7.fs: domain 2 of 9, from 253 to 379: score 18.7, E = 8.1e-05 *->qsqvtqepprWGLLLASLfW.p.t........svtvaeGgsvtLpCt +s v++ p+ +W+ +++ ++ + v+v+eG++ +++C+ hg00295 253 ASAVET-RPS--------IWgEcPpkfatklgRVVVKEGQMGRFSCK 290 ysGtfddsssssgtfsiyWyrqqppgkgpeliiisyysyystsegngtvg + + + ++ +++W + ++ hg00295 291 IT---GRP----QP-QVTWLK-GNV------------------------- 306 erfkgrvtlsgnpskgdfsLtIsnlqlsDsGtYyCavsns.......... +++ + ++s++ +g L I+ + ++D G+Y+C v n++++ + + + hg00295 307 -PLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGsgkasmsael 355 ..........nelvfgggtrLtVl<-* + ++ ++ +++++ + t+ V+ hg00295 356 siqgldsanrSFVRETKATNSDVR 379 PF07679.6.fs: domain 2 of 9, from 268 to 357: score 121.3, E = 8.9e-35 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp PkF +k+ +v+V+eG+ rf+Ck+tG P+P+V+W+K++ pl++ hg00295 268 PKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQP---- 310 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< s r++v++++ g + L+I +v+ dD G+YtC + N +G+a+ saeL + hg00295 311 SARVSVSEKN--GMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 357 -* hg00295 - - PF07679.6.ls: domain 2 of 9, from 268 to 357: score 123.3, E = 6.5e-34 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp PkF +k+ +v+V+eG+ rf+Ck+tG P+P+V+W+K++ pl++ hg00295 268 PKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQP---- 310 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< s r++v++++ g + L+I +v+ dD G+YtC + N +G+a+ saeL + hg00295 311 SARVSVSEKN--GMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 357 -* hg00295 - - PF00047.15.fs: domain 2 of 9, from 282 to 342: score 38.4, E = 9e-10 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G++ +++C +g p+++vtWl+++ +l+++ +v +se ng ++ hg00295 282 GQMGRFSCKI--TGRPQPQVTWLKGNVpLQpSARVSVSEKNGMQV-- 324 tsLtitnvtpeDggtYtCvv<-* L i+ v ++D g+YtC v hg00295 325 --LEIHGVNQDDVGVYTCLV 342 PF00047.15.ls: domain 2 of 9, from 282 to 342: score 40.3, E = 6.3e-09 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G++ +++C +g p+++vtWl+++ +l+++ +v +se ng ++ hg00295 282 GQMGRFSCKI--TGRPQPQVTWLKGNVpLQpSARVSVSEKNGMQV-- 324 tsLtitnvtpeDggtYtCvv<-* L i+ v ++D g+YtC v hg00295 325 --LEIHGVNQDDVGVYTCLV 342 PF07686.7.ls: domain 3 of 9, from 456 to 612: score 12.7, E = 0.0026 *->qsqvtqepprWGLLLASLfWp.t........................ + v++ pr +++ + ++++++++++ ++++ + ++ hg00295 456 AARVQP-EPR----------ApGlgvlspsgeerkrpapprpatfpt 491 .....................................svtvaeGgsvtLp ++++ ++++ ++ +++ + ++++++ ++ +++++s v+e ++v+++ hg00295 492 rqpglgsqdvvskaanrripmegqrdsafpkfeskpqSQEVKENQTVKFR 541 CtysGtfddsssssgtfsiyWyrqqppgkgpeliiisyysyystsegngt C +s + + ++ W+ gt hg00295 542 CEVS----GI----PKPEVAWFL------------------------EGT 559 vgerfkgrvtlsgnpskgdfsLtIsnlqlsDsGtYyCavsnsnelvfggg + r g+++++ + + + +L + +++ DsGtY C sn ++ hg00295 560 PVRRQEGSIEVYEDAG--SHYLCLLKARTRDSGTYSCTASNA-QGQVSCS 606 trLtVl<-* +L+V+ hg00295 607 WTLQVE 612 PF07679.6.fs: domain 3 of 9, from 521 to 611: score 102.3, E = 3.1e-29 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp PkF+ kp+++eV+e ++++f C+V+G P+P+V Wf G p++ hg00295 521 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRR---Q 564 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< ++ + v +d g + L +++ +DsG+Y+C+A+N G++++s +L+V hg00295 565 EGSIEVYEDA--GSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQV 611 -* hg00295 - - PF07679.6.ls: domain 3 of 9, from 521 to 611: score 104.2, E = 3.4e-28 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp PkF+ kp+++eV+e ++++f C+V+G P+P+V Wf G p++ hg00295 521 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRR---Q 564 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< ++ + v +d g + L +++ +DsG+Y+C+A+N G++++s +L+V hg00295 565 EGSIEVYEDA--GSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQV 611 -* hg00295 - - PF00047.15.fs: domain 3 of 9, from 535 to 596: score 33.5, E = 1.9e-08 *->GesvtLtCsvsgfgppdvtvtWlrngk.ltgvlvtssenngdstyqt +++v+++C+v +g p ++v W+ +g+++ +++ + ++++ ++ + hg00295 535 NQTVKFRCEV--SGIPKPEVAWFLEGTpVRRQEGSIEVYEDAGSHY- 578 sLtitnvtpeDggtYtCvv<-* L +++++ D+gtY+C++ hg00295 579 -LCLLKARTRDSGTYSCTA 596 PF00047.15.ls: domain 3 of 9, from 535 to 596: score 35.4, E = 1.8e-07 *->GesvtLtCsvsgfgppdvtvtWlrngk.ltgvlvtssenngdstyqt +++v+++C+v +g p ++v W+ +g+++ +++ + ++++ ++ + hg00295 535 NQTVKFRCEV--SGIPKPEVAWFLEGTpVRRQEGSIEVYEDAGSHY- 578 sLtitnvtpeDggtYtCvv<-* L +++++ D+gtY+C++ hg00295 579 -LCLLKARTRDSGTYSCTA 596 PF07679.6.ls: domain 4 of 9, from 621 to 707: score 96.8, E = 6e-26 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+F+ ++kd V eG++ +++C V+GtP P ++W+ +Gqp++ hg00295 621 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQ----- 662 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< + t++ g + L I+++ p+D G+YtC A+N G++++sa +tV hg00295 663 --YARSTCEA--GVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTV 707 -* hg00295 - - PF07679.6.fs: domain 4 of 9, from 621 to 707: score 94.9, E = 4.5e-27 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+F+ ++kd V eG++ +++C V+GtP P ++W+ +Gqp++ hg00295 621 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQ----- 662 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< + t++ g + L I+++ p+D G+YtC A+N G++++sa +tV hg00295 663 --YARSTCEA--GVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTV 707 -* hg00295 - - PF07686.7.ls: domain 4 of 9, from 623 to 708: score 14.1, E = 0.0019 *->qsqvtqepprWGLLLASLfWptsvtvaeGgsvtLpCtysGtfddsss s+v + v eG++ L+C+++ ++ hg00295 623 FSSVLK--DC--------------AVIEGQDFVLQCSVR----GT-- 647 ssgtfsiyWyrqqppgkgpeliiisyysyystsegngtvgerfkgrvtls ++ +i+W +++p + + + +++ hg00295 648 --PVPRITWLL----NGQPIQYA--------------------RSTCE-- 669 gnpskgdfsLtIsnlqlsDsGtYyCavsnsnelvfgggtrLtVl<-* g + L+I+++ ++D GtY+C n ++ ++tV+ hg00295 670 ----AGVAELHIQDALPEDHGTYTCLAENA-LGQVSCSAWVTVH 708 PF00047.15.ls: domain 4 of 9, from 635 to 692: score 43.6, E = 6e-10 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+++ L+Csv g+p +++tWl ng++++ ++ + hg00295 635 GQDFVLQCSV--RGTPVPRITWLLNGQpIQyARSTCEAGVAE----- 674 tsLtitnvtpeDggtYtCvv<-* L+i+++ peD gtYtC + hg00295 675 --LHIQDALPEDHGTYTCLA 692 PF00047.15.fs: domain 4 of 9, from 635 to 692: score 41.8, E = 1e-10 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+++ L+Csv g+p +++tWl ng++++ ++ + hg00295 635 GQDFVLQCSV--RGTPVPRITWLLNGQpIQyARSTCEAGVAE----- 674 tsLtitnvtpeDggtYtCvv<-* L+i+++ peD gtYtC + hg00295 675 --LHIQDALPEDHGTYTCLA 692 PF07686.7.fs: domain 5 of 9, from 730 to 820: score 21.2, E = 1.6e-05 *->qsqvtqepprWGLLLASLfWptsvtvaeGgsvtLpCtysGtfddsss ++ +++ + + v G vt++ ++s hg00295 730 PIFLQG--LS------------DLKVMDGSQVTMTVQVS-------- 754 ssgtfsiyWyrqqppgkgpeliiisyysyystsegngtvgerfkgrvtls g++p ++i + ++ + + + ++ +++ hg00295 755 ---------------GNPPPEVI------WLHN----GNEIQESEDFHFE 779 gnpskgdfsLtIsnlqlsDsGtYyCavsnsnelvfgggtrLtVl<-* + ++ sL I+ + ++D+GtY+C +ns ++ + +LtV hg00295 780 QRGT--QHSLCIQEVFPEDTGTYTCEAWNS-AGEVRTQAVLTVQ 820 PF07686.7.ls: domain 5 of 9, from 730 to 820: score 22.9, E = 0.00024 *->qsqvtqepprWGLLLASLfWptsvtvaeGgsvtLpCtysGtfddsss ++ +++ + + v G vt++ ++s hg00295 730 PIFLQG--LS------------DLKVMDGSQVTMTVQVS-------- 754 ssgtfsiyWyrqqppgkgpeliiisyysyystsegngtvgerfkgrvtls g++p ++i + ++ + + + ++ +++ hg00295 755 ---------------GNPPPEVI------WLHN----GNEIQESEDFHFE 779 gnpskgdfsLtIsnlqlsDsGtYyCavsnsnelvfgggtrLtVl<-* + ++ sL I+ + ++D+GtY+C +ns ++ + +LtV hg00295 780 QRGT--QHSLCIQEVFPEDTGTYTCEAWNS-AGEVRTQAVLTVQ 820 PF07679.6.fs: domain 5 of 9, from 730 to 819: score 113.7, E = 1.5e-32 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P F+q ++d++V+ G+ ++++++V+G+P+P+V W+++G ++++ hg00295 730 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQE---- 772 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< s+ f++ +g ++L I++v+p+D G+YtC A NsaGe+ + a LtV hg00295 773 SEDFHFEQRG--TQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTV 819 -* hg00295 - - PF07679.6.ls: domain 5 of 9, from 730 to 819: score 115.6, E = 1.3e-31 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P F+q ++d++V+ G+ ++++++V+G+P+P+V W+++G ++++ hg00295 730 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQE---- 772 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< s+ f++ +g ++L I++v+p+D G+YtC A NsaGe+ + a LtV hg00295 773 SEDFHFEQRG--TQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTV 819 -* hg00295 - - PF00047.15.fs: domain 5 of 9, from 744 to 804: score 45.5, E = 1e-11 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+ vt+t +v +g+p+++v Wl+ng +++++++ ++ +++++++ hg00295 744 GSQVTMTVQV--SGNPPPEVIWLHNGNeIQeSEDFHFEQRGTQHS-- 786 tsLtitnvtpeDggtYtCvv<-* L i++v peD+gtYtC++ hg00295 787 --LCIQEVFPEDTGTYTCEA 804 PF00047.15.ls: domain 5 of 9, from 744 to 804: score 47.4, E = 4.6e-11 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+ vt+t +v +g+p+++v Wl+ng +++++++ ++ +++++++ hg00295 744 GSQVTMTVQV--SGNPPPEVIWLHNGNeIQeSEDFHFEQRGTQHS-- 786 tsLtitnvtpeDggtYtCvv<-* L i++v peD+gtYtC++ hg00295 787 --LCIQEVFPEDTGTYTCEA 804 PF07686.7.fs: domain 6 of 9, from 828 to 893: score 20.6, E = 2.4e-05 *->qsqvtqepprWGLLLASLfWptsvtvaeGgsvtLpCtysGtfddsss + ++ pr svt+++G+sv+++C +d+ hg00295 828 PWFISK--PR------------SVTASLGQSVLISCAIA---GDP-- 855 ssgtfsiyWyrq.qppgkgpeliiisyysyystsegngtvgerfkgrvtl + +++W r++ + +k++ ++ hg00295 856 --FP-TVHWLRDgKAL---------------------------CKDTGHF 875 sgnpskgdfsLtIsnlql<-* + + + f+L ++++q+ hg00295 876 EVLQNEDVFTLVLKKVQP 893 PF07679.6.ls: domain 6 of 9, from 828 to 918: score 74.4, E = 3.4e-19 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P F+ kp++v+++ G+s+ +C + G+P PtV W++dG+ l + hg00295 828 PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCK---D 871 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< +++f v ++ + tL+ ++vqp +G+Y + +N++Ge+++ ++L hg00295 872 TGHFEVLQNE--DVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLML 918 -* hg00295 - - PF07679.6.fs: domain 6 of 9, from 828 to 918: score 72.4, E = 1.6e-20 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P F+ kp++v+++ G+s+ +C + G+P PtV W++dG+ l + hg00295 828 PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCK---D 871 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< +++f v ++ + tL+ ++vqp +G+Y + +N++Ge+++ ++L hg00295 872 TGHFEVLQNE--DVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLML 918 -* hg00295 - - PF07686.7.ls: domain 6 of 9, from 828 to 919: score 18.7, E = 0.00064 *->qsqvtqepprWGLLLASLfWptsvtvaeGgsvtLpCtysGtfddsss + ++ pr svt+++G+sv+++C +d+ hg00295 828 PWFISK--PR------------SVTASLGQSVLISCAIA---GDP-- 855 ssgtfsiyWyrq.qppgkgpeliiisyysyystsegngtvgerfkgrvtl + +++W r++ + +k++ ++ hg00295 856 --FP-TVHWLRDgKAL---------------------------CKDTGHF 875 sgnpskgdfsLtIsnlqlsDsGtYyCavsnsnelvfgggtrLtVl<-* + + + f+L ++++q+ + G Y +n ++ + L+ hg00295 876 EVLQNEDVFTLVLKKVQPWHAGQYEILLKNR-VGECSCQVSLMLQ 919 PF00047.15.fs: domain 6 of 9, from 842 to 899: score 25.5, E = 3e-06 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+sv ++C g+p +tv+Wlr+gk l +++ + ++ +n d ++ hg00295 842 GQSVLISCAI--AGDPFPTVHWLRDGKaLCkDTGHFEVLQNEDVFT- 885 tsLtitnvtpeDggtY<-* L++++v+p ++g Y hg00295 886 --LVLKKVQPWHAGQY 899 PF00047.15.ls: domain 6 of 9, from 842 to 903: score 22.4, E = 0.0016 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+sv ++C g+p +tv+Wlr+gk l +++ + ++ +n d ++ hg00295 842 GQSVLISCAI--AGDPFPTVHWLRDGKaLCkDTGHFEVLQNEDVFT- 885 tsLtitnvtpeDggtYtCvv<-* L++++v+p ++g Y hg00295 886 --LVLKKVQPWHAGQYEILL 903 PF07686.7.ls: domain 7 of 9, from 1205 to 1295: score 13.8, E = 0.002 *->qsqvtqepprWGLLLASLfWptsvtvaeGgsvtLpCtysGtfddsss + + v+vaeG++++L+C++s +d+ hg00295 1205 PAFKQK--LQ------------DVHVAEGKKLLLQCQVS---SDP-- 1232 ssgtfsiyWyrq.qppgkgpeliiisyysyystsegngtvgerfkgrvtl + +i W ++ ++ k + ++ hg00295 1233 --PA-TIIWTLNgKTL----------------------------KTTKFI 1251 sgnpskgdfsLtIsnlqlsDsGtYyCavsnsnelvfgggtrLtVl<-* + ++ +s++I ++ ++D G Y C+ +n + ++ + ++tV hg00295 1252 ILSQEGSLCSVSIEKALPEDRGLYKCVAKN-DAGQAECSCQVTVD 1295 PF07679.6.ls: domain 7 of 9, from 1205 to 1294: score 93.8, E = 4.7e-25 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P F qk++dv V+eG+ + ++C+V+ +P+ t+ W+ +G+ l+ hg00295 1205 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKT---- 1247 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< ++ + + +g ++ I ++ p+D G+Y+CvA+N aG+ae+s+++tV hg00295 1248 TKFIILSQEG--SLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTV 1294 -* hg00295 - - PF07679.6.fs: domain 7 of 9, from 1205 to 1294: score 91.9, E = 3.4e-26 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P F qk++dv V+eG+ + ++C+V+ +P+ t+ W+ +G+ l+ hg00295 1205 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKT---- 1247 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< ++ + + +g ++ I ++ p+D G+Y+CvA+N aG+ae+s+++tV hg00295 1248 TKFIILSQEG--SLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTV 1294 -* hg00295 - - PF00047.15.ls: domain 7 of 9, from 1219 to 1279: score 40.0, E = 7.6e-09 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+++ L+C+v +++p++t+ W+ ngk+l + + s++++ + hg00295 1219 GKKLLLQCQV--SSDPPATIIWTLNGKtLKtTKFIILSQEGSLCS-- 1261 tsLtitnvtpeDggtYtCvv<-* ++i ++ peD g Y+Cv+ hg00295 1262 --VSIEKALPEDRGLYKCVA 1279 PF00047.15.fs: domain 7 of 9, from 1219 to 1279: score 38.1, E = 1.1e-09 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+++ L+C+v +++p++t+ W+ ngk+l + + s++++ + hg00295 1219 GKKLLLQCQV--SSDPPATIIWTLNGKtLKtTKFIILSQEGSLCS-- 1261 tsLtitnvtpeDggtYtCvv<-* ++i ++ peD g Y+Cv+ hg00295 1262 --VSIEKALPEDRGLYKCVA 1279 PF07686.7.ls: domain 8 of 9, from 1344 to 1435: score 13.1, E = 0.0023 *->qsqvtqepprWGLLLASLfWptsvtvaeGgsvtLpCtysGtfddsss + q+ q p+ v G+sv+L +++ ++ hg00295 1344 PPQIIQ-FPE------------DQKVRAGESVELFGKVT----GT-- 1371 ssgtfsiyWyrqqppgkgpeliiisyysyystsegngtvgerfkgrvtls ++ + +W++ + +++ + +v+++ +g+ hg00295 1372 --QPITCTWMK-FRK--------------QIQESEHMKVENSENGSK--- 1401 gnpskgdfsLtIsnlqlsDsGtYyCavsnsnelvfgggtrLtVl<-* LtI +++++ G+Y+ v n ++ ++ ++LtV+ hg00295 1402 ---------LTILAARQEHCGCYTLLVENK-LGSRQAQVNLTVV 1435 PF07679.6.ls: domain 8 of 9, from 1345 to 1434: score 76.4, E = 8.3e-20 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+++q p+d++V+ Ges+++ kVtGt + t +W K +++++ hg00295 1345 PQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQE---- 1387 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< s+++kv +++ + ++LtI+ + + G Yt ++N+ G+ +a ++LtV hg00295 1388 SEHMKVENSE--NGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTV 1434 -* hg00295 - - PF07679.6.fs: domain 8 of 9, from 1345 to 1434: score 74.5, E = 4.1e-21 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+++q p+d++V+ Ges+++ kVtGt + t +W K +++++ hg00295 1345 PQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQE---- 1387 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< s+++kv +++ + ++LtI+ + + G Yt ++N+ G+ +a ++LtV hg00295 1388 SEHMKVENSE--NGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTV 1434 -* hg00295 - - PF00041.11.fs: domain 1 of 1, from 1438 to 1523: score 80.1, E = 2.3e-22 *->PsaP.tnltvtdvtstsltlsWspPt..gngpitgYevtyRqpkngg P++P + + ++d++s+sltlsW ++ +g++ +++Y+++ +++ + hg00295 1438 PDPPaGTPCASDIRSSSLTLSWYGSSydGGSAVQSYSIEI-WDS-AN 1482 e.wkeltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* ++wkel + ++t s+++++L P+ eY++rV+A+n G++++S hg00295 1483 KtWKELATCRST-SFNVQDLLPDHEYKFRVRAINVYGtSEPS 1523 PF00041.11.ls: domain 1 of 1, from 1438 to 1523: score 82.1, E = 1.6e-21 *->PsaP.tnltvtdvtstsltlsWspPt..gngpitgYevtyRqpkngg P++P + + ++d++s+sltlsW ++ +g++ +++Y+++ +++ + hg00295 1438 PDPPaGTPCASDIRSSSLTLSWYGSSydGGSAVQSYSIEI-WDS-AN 1482 e.wkeltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* ++wkel + ++t s+++++L P+ eY++rV+A+n G++++S hg00295 1483 KtWKELATCRST-SFNVQDLLPDHEYKFRVRAINVYGtSEPS 1523 PF00069.15.ls: domain 1 of 1, from 1571 to 1826: score 353.9, E = 2.4e-103 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y ++e+lGsG fG+V++ ++k+t+k++A K +k ++k+k++++ hg00295 1571 YDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQ-- 1615 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse Ei+i++ L+Hp v++ d+fe+k ++ +VlE + gG +Lf+++ hg00295 1616 --EISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGG----ELFERII- 1658 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld.nng +++ l +e+e++k+++Qi +g+eY+H++gi+H DLKPeNI++++++g hg00295 1659 -DEDFEL--TERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVnKTG 1705 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv + +K++DFGlA+ +++ ++l+++ GTp+++APEv++ ++++g++ hg00295 1706 TR---IKLIDFGLARR--LeNAGsLKVLFGTPEFVAPEVIN-YEPIGYAT 1749 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+WS+Gvi+y+l++G PF g+ ++++ ++++ ++ ++fd + d+ hg00295 1750 DMWSIGVICYILVSGLSPFMGD-----NDNETLANVTSATWDFDDEAFDE 1794 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* is ++akd+i+++L+kD++ Rl ++++lqHPw+ hg00295 1795 IS-----------DDAKDFISNLLKKDMKNRLDCTQCLQHPWL 1826 PF00069.15.fs: domain 1 of 1, from 1571 to 1826: score 352.0, E = 8.9e-103 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y ++e+lGsG fG+V++ ++k+t+k++A K +k ++k+k++++ hg00295 1571 YDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQ-- 1615 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse Ei+i++ L+Hp v++ d+fe+k ++ +VlE + gG +Lf+++ hg00295 1616 --EISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGG----ELFERII- 1658 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld.nng +++ l +e+e++k+++Qi +g+eY+H++gi+H DLKPeNI++++++g hg00295 1659 -DEDFEL--TERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVnKTG 1705 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv + +K++DFGlA+ +++ ++l+++ GTp+++APEv++ ++++g++ hg00295 1706 TR---IKLIDFGLARR--LeNAGsLKVLFGTPEFVAPEVIN-YEPIGYAT 1749 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+WS+Gvi+y+l++G PF g+ ++++ ++++ ++ ++fd + d+ hg00295 1750 DMWSIGVICYILVSGLSPFMGD-----NDNETLANVTSATWDFDDEAFDE 1794 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* is ++akd+i+++L+kD++ Rl ++++lqHPw+ hg00295 1795 IS-----------DDAKDFISNLLKKDMKNRLDCTQCLQHPWL 1826 PF07714.7.fs: domain 1 of 1, from 1571 to 1693: score 37.9, E = 6.7e-11 *->lklgkkLGeGaFGeVykGtlkgsgdgteikV.AVKtLkeigaseeei + + LG+G FG V++ + k ++ kV A K k ++ e hg00295 1571 YDIEERLGSGKFGQVFRLVEK-----KTRKVwAGKFFKA-YSAKE-- 1609 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd +e +E+siM l +Hp++V++ + + + + +V+E + gG hg00295 1610 -KENIRQEISIMNCL-HHPKLVQCVDAFEE-KAN----IVMVLEIVSGGE 1652 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDL<-* L + + + Lt + +++++Qi++G eY + +++vH DL hg00295 1653 LFERIIDE--DFELTERECIKYMRQISEGVEYIHKQGIVHLDL 1693 PF07679.6.ls: domain 9 of 9, from 1915 to 2005: score 167.7, E = 2.8e-47 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+F++ ++d+eV eG++arf+Ck++G+P+P+V WfKd+q +++ hg00295 1915 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRE---- 1957 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< s++f+++yd+ +g+++L+Is+v+ dD kYtC+A Ns Gea+++aeL+V hg00295 1958 SRHFQIDYDE-DGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV 2005 -* hg00295 - - PF07679.6.fs: domain 9 of 9, from 1915 to 2005: score 165.7, E = 1e-47 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+F++ ++d+eV eG++arf+Ck++G+P+P+V WfKd+q +++ hg00295 1915 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRE---- 1957 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< s++f+++yd+ +g+++L+Is+v+ dD kYtC+A Ns Gea+++aeL+V hg00295 1958 SRHFQIDYDE-DGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV 2005 -* hg00295 - - PF00047.15.fs: domain 9 of 9, from 1929 to 1990: score 32.2, E = 4.3e-08 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+ +++ C +g pd++v W+++++++ ++ + ++ ++++ + hg00295 1929 GSAARFDCKI--EGYPDPEVVWFKDDQsIReSRHFQIDYDEDGNCS- 1972 tsLtitnvtpeDggtYtCvv<-* L i++v +D++ YtC + hg00295 1973 --LIISDVCGDDDAKYTCKA 1990 PF00047.15.ls: domain 9 of 9, from 1929 to 1990: score 34.1, E = 4.4e-07 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+ +++ C +g pd++v W+++++++ ++ + ++ ++++ + hg00295 1929 GSAARFDCKI--EGYPDPEVVWFKDDQsIReSRHFQIDYDEDGNCS- 1972 tsLtitnvtpeDggtYtCvv<-* L i++v +D++ YtC + hg00295 1973 --LIISDVCGDDDAKYTCKA 1990 //