# /hgtech/tools/solaris8/bin/fasta34_t -T 8 -b50 -d10 -E0.01 -H -Ohj00278.fasta.nr -Q hj00278.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 hj00278, 1289 aa vs /cdna2/lib/nr/nr library 2362217958 residues in 6843189 sequences statistics sampled from 60000 to 6840972 sequences Expectation_n fit: rho(ln(x))= 5.1381+/-0.000187; mu= 15.3648+/- 0.010 mean_var=80.8476+/-15.916, 0's: 41 Z-trim: 51 B-trim: 8 in 1/67 Lambda= 0.142640 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 40, opt: 28, open/ext: -10/-2, width: 16 The best scores are: opt bits E(6843189) gi|62087676|dbj|BAD92285.1| Niemann-Pick disease, (1289) 8767 1814.9 0 gi|83305902|sp|O15118|NPC1_HUMAN Niemann-Pick C1 p (1278) 8685 1798.0 0 gi|13430254|gb|AAK25791.1|AF338230_1 Niemann-Pick (1278) 8680 1797.0 0 gi|38649260|gb|AAH63302.1| Niemann-Pick disease, t (1278) 8675 1796.0 0 gi|114672573|ref|XP_001155285.1| PREDICTED: Nieman (1277) 8584 1777.2 0 gi|114672577|ref|XP_001155163.1| PREDICTED: Nieman (1261) 8419 1743.3 0 gi|114672571|ref|XP_001155116.1| PREDICTED: Nieman (1285) 8409 1741.2 0 gi|114672579|ref|XP_512062.2| PREDICTED: Niemann-P (1217) 8075 1672.5 0 gi|6581072|gb|AAF18444.1|AF202730_1 Niemann-Pick t (1286) 8071 1671.7 0 gi|20531742|gb|AAM27451.1| Niemann-Pick C1 [Felis (1276) 8048 1666.9 0 gi|8099648|gb|AAF72187.1|AF258783_1 Niemann-Pick t (1276) 8040 1665.3 0 gi|20531740|gb|AAM27450.1| mutant Niemann-Pick C1 (1276) 8034 1664.0 0 gi|194214517|ref|XP_001490228.2| PREDICTED: simila (1293) 7981 1653.1 0 gi|8134591|sp|P56941|NPC1_PIG Niemann-Pick C1 prot (1277) 7945 1645.7 0 gi|154425876|gb|AAI51277.1| NPC1 protein [Bos taur (1277) 7915 1639.6 0 gi|11878263|gb|AAG40873.1|AF315034_1 Niemann-Pick (1276) 7904 1637.3 0 gi|10945625|gb|AAG24620.1|AF299073_1 Niemann-Pick (1277) 7848 1625.8 0 gi|6934272|gb|AAF31692.1|AF182744_1 Niemann-Pick t (1277) 7755 1606.6 0 gi|148669613|gb|EDL01560.1| Niemann Pick type C1 [ (1277) 7719 1599.2 0 gi|30851359|gb|AAH52437.1| Niemann Pick type C1 [M (1277) 7714 1598.2 0 gi|149031745|gb|EDL86695.1| rCG41239 [Rattus norve (1278) 7701 1595.5 0 gi|8134596|sp|O35604|NPC1_MOUSE Niemann-Pick C1 pr (1278) 7683 1591.8 0 gi|126321789|ref|XP_001365874.1| PREDICTED: simila (1280) 7507 1555.6 0 gi|114672575|ref|XP_001155222.1| PREDICTED: Nieman (1122) 7502 1554.5 0 gi|118086893|ref|XP_419162.2| PREDICTED: similar t (1261) 6986 1448.4 0 gi|74178457|dbj|BAE32486.1| unnamed protein produc (1094) 6575 1363.7 0 gi|194380812|dbj|BAG58559.1| unnamed protein produ ( 776) 5263 1093.6 0 gi|194375700|dbj|BAG57194.1| unnamed protein produ ( 960) 4549 946.8 0 gi|72076342|ref|XP_780036.1| PREDICTED: similar to (1332) 3649 761.7 0 gi|190616752|gb|EDV32276.1| GF14130 [Drosophila an (1286) 3636 759.0 3.7e-216 gi|194130326|gb|EDW52369.1| GM11941 [Drosophila se (1287) 3636 759.0 3.7e-216 gi|10728700|gb|AAF52874.2| CG5722-PA [Drosophila m (1287) 3617 755.1 5.6e-215 gi|33589358|gb|AAQ22446.1| RE56428p [Drosophila me (1287) 3611 753.9 1.3e-214 gi|5921280|emb|CAB56505.1| NPC1 protein [Drosophil (1287) 3610 753.6 1.5e-214 gi|194175146|gb|EDW88757.1| GE26328 [Drosophila ya (1287) 3598 751.2 8.5e-214 gi|193914689|gb|EDW13556.1| GI18274 [Drosophila mo (1253) 3528 736.8 1.8e-209 gi|194141077|gb|EDW57496.1| GJ18108 [Drosophila vi (1282) 3496 730.2 1.8e-207 gi|190582487|gb|EDV22560.1| hypothetical protein T (1218) 3372 704.7 8.1e-200 gi|189241956|ref|XP_967619.2| PREDICTED: similar t (1306) 3310 691.9 5.9e-196 gi|110761346|ref|XP_624752.2| PREDICTED: similar t (1358) 3168 662.7 3.8e-187 gi|194209530|ref|XP_001495852.2| PREDICTED: simila (1329) 3126 654.1 1.5e-184 gi|194190896|gb|EDX04472.1| GD22294 [Drosophila si (1251) 2957 619.3 4.2e-174 gi|189515564|ref|XP_001919958.1| PREDICTED: im:714 ( 598) 2884 604.0 8.2e-170 gi|117188120|gb|ABK32538.1| Niemann-Pick C1-like 1 (1328) 2863 599.9 2.9e-168 gi|126361942|gb|AAI31789.1| Npc1l1 protein [Mus mu (1332) 2854 598.1 1.1e-167 gi|73921246|sp|Q6T3U4|NPCL1_MOUSE Niemann-Pick C1- (1333) 2854 598.1 1.1e-167 gi|56206134|emb|CAI24395.1| NPC1-like 1 [Mus muscu (1333) 2854 598.1 1.1e-167 gi|73921247|sp|Q6T3U3|NPCL1_RAT Niemann-Pick C1-li (1331) 2830 593.1 3.3e-166 gi|117188115|gb|ABK32537.1| Niemann-Pick C1-like 1 (1325) 2819 590.9 1.6e-165 gi|117188100|gb|ABK32534.1| Niemann-Pick C1-like 1 (1325) 2795 585.9 4.8e-164 >>gi|62087676|dbj|BAD92285.1| Niemann-Pick disease, type (1289 aa) initn: 8767 init1: 8767 opt: 8767 Z-score: 9742.3 bits: 1814.9 E(): 0 Smith-Waterman score: 8767; 100.000% identity (100.000% similar) in 1289 aa overlap (1-1289:1-1289) 10 20 30 40 50 60 hj0027 PPASAALRGHSMTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 PPASAALRGHSMTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK 10 20 30 40 50 60 70 80 90 100 110 120 hj0027 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC 70 80 90 100 110 120 130 140 150 160 170 180 hj0027 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN 130 140 150 160 170 180 190 200 210 220 230 240 hj0027 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVRGMEPMNNATKGCDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVRGMEPMNNATKGCDE 190 200 210 220 230 240 250 260 270 280 290 300 hj0027 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA 250 260 270 280 290 300 310 320 330 340 350 360 hj0027 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN 310 320 330 340 350 360 370 380 390 400 410 420 hj0027 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI 370 380 390 400 410 420 430 440 450 460 470 480 hj0027 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL 430 440 450 460 470 480 490 500 510 520 530 540 hj0027 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL 490 500 510 520 530 540 550 560 570 580 590 600 hj0027 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN 550 560 570 580 590 600 610 620 630 640 650 660 hj0027 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLL 610 620 630 640 650 660 670 680 690 700 710 720 hj0027 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY 670 680 690 700 710 720 730 740 750 760 770 780 hj0027 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF 730 740 750 760 770 780 790 800 810 820 830 840 hj0027 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL 790 800 810 820 830 840 850 860 870 880 890 900 hj0027 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV 850 860 870 880 890 900 910 920 930 940 950 960 hj0027 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW 910 920 930 940 950 960 970 980 990 1000 1010 1020 hj0027 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 hj0027 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 hj0027 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 hj0027 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 hj0027 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|620 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS 1210 1220 1230 1240 1250 1260 1270 1280 hj0027 YIGPSVNKAKSCATEERYKGTERERLLNF ::::::::::::::::::::::::::::: gi|620 YIGPSVNKAKSCATEERYKGTERERLLNF 1270 1280 >>gi|83305902|sp|O15118|NPC1_HUMAN Niemann-Pick C1 prote (1278 aa) initn: 8685 init1: 8685 opt: 8685 Z-score: 9651.1 bits: 1798.0 E(): 0 Smith-Waterman score: 8685; 99.922% identity (100.000% similar) in 1278 aa overlap (12-1289:1-1278) 10 20 30 40 50 60 hj0027 PPASAALRGHSMTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK ::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 MTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK 10 20 30 40 70 80 90 100 110 120 hj0027 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC 50 60 70 80 90 100 130 140 150 160 170 180 hj0027 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN 110 120 130 140 150 160 190 200 210 220 230 240 hj0027 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVRGMEPMNNATKGCDE :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|833 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDE 170 180 190 200 210 220 250 260 270 280 290 300 hj0027 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA 230 240 250 260 270 280 310 320 330 340 350 360 hj0027 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN 290 300 310 320 330 340 370 380 390 400 410 420 hj0027 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI 350 360 370 380 390 400 430 440 450 460 470 480 hj0027 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL 410 420 430 440 450 460 490 500 510 520 530 540 hj0027 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL 470 480 490 500 510 520 550 560 570 580 590 600 hj0027 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN 530 540 550 560 570 580 610 620 630 640 650 660 hj0027 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLL 590 600 610 620 630 640 670 680 690 700 710 720 hj0027 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY 650 660 670 680 690 700 730 740 750 760 770 780 hj0027 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF 710 720 730 740 750 760 790 800 810 820 830 840 hj0027 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL 770 780 790 800 810 820 850 860 870 880 890 900 hj0027 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV 830 840 850 860 870 880 910 920 930 940 950 960 hj0027 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW 890 900 910 920 930 940 970 980 990 1000 1010 1020 hj0027 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 hj0027 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 hj0027 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 hj0027 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 hj0027 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|833 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS 1190 1200 1210 1220 1230 1240 1270 1280 hj0027 YIGPSVNKAKSCATEERYKGTERERLLNF ::::::::::::::::::::::::::::: gi|833 YIGPSVNKAKSCATEERYKGTERERLLNF 1250 1260 1270 >>gi|13430254|gb|AAK25791.1|AF338230_1 Niemann-Pick dise (1278 aa) initn: 8680 init1: 8680 opt: 8680 Z-score: 9645.6 bits: 1797.0 E(): 0 Smith-Waterman score: 8680; 99.844% identity (100.000% similar) in 1278 aa overlap (12-1289:1-1278) 10 20 30 40 50 60 hj0027 PPASAALRGHSMTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK ::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 MTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK 10 20 30 40 70 80 90 100 110 120 hj0027 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC 50 60 70 80 90 100 130 140 150 160 170 180 hj0027 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN 110 120 130 140 150 160 190 200 210 220 230 240 hj0027 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVRGMEPMNNATKGCDE :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|134 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDE 170 180 190 200 210 220 250 260 270 280 290 300 hj0027 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA 230 240 250 260 270 280 310 320 330 340 350 360 hj0027 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN 290 300 310 320 330 340 370 380 390 400 410 420 hj0027 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI 350 360 370 380 390 400 430 440 450 460 470 480 hj0027 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL 410 420 430 440 450 460 490 500 510 520 530 540 hj0027 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL 470 480 490 500 510 520 550 560 570 580 590 600 hj0027 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN 530 540 550 560 570 580 610 620 630 640 650 660 hj0027 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: gi|134 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLL 590 600 610 620 630 640 670 680 690 700 710 720 hj0027 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY 650 660 670 680 690 700 730 740 750 760 770 780 hj0027 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF 710 720 730 740 750 760 790 800 810 820 830 840 hj0027 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL 770 780 790 800 810 820 850 860 870 880 890 900 hj0027 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV 830 840 850 860 870 880 910 920 930 940 950 960 hj0027 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW 890 900 910 920 930 940 970 980 990 1000 1010 1020 hj0027 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 hj0027 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 hj0027 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 hj0027 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 hj0027 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|134 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS 1190 1200 1210 1220 1230 1240 1270 1280 hj0027 YIGPSVNKAKSCATEERYKGTERERLLNF ::::::::::::::::::::::::::::: gi|134 YIGPSVNKAKSCATEERYKGTERERLLNF 1250 1260 1270 >>gi|38649260|gb|AAH63302.1| Niemann-Pick disease, type (1278 aa) initn: 8675 init1: 8675 opt: 8675 Z-score: 9640.0 bits: 1796.0 E(): 0 Smith-Waterman score: 8675; 99.765% identity (100.000% similar) in 1278 aa overlap (12-1289:1-1278) 10 20 30 40 50 60 hj0027 PPASAALRGHSMTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK ::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 MTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK 10 20 30 40 70 80 90 100 110 120 hj0027 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC 50 60 70 80 90 100 130 140 150 160 170 180 hj0027 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: gi|386 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQGFANAMYNACRDVEAPSSN 110 120 130 140 150 160 190 200 210 220 230 240 hj0027 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVRGMEPMNNATKGCDE :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|386 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDE 170 180 190 200 210 220 250 260 270 280 290 300 hj0027 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA 230 240 250 260 270 280 310 320 330 340 350 360 hj0027 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN 290 300 310 320 330 340 370 380 390 400 410 420 hj0027 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI 350 360 370 380 390 400 430 440 450 460 470 480 hj0027 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL 410 420 430 440 450 460 490 500 510 520 530 540 hj0027 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL 470 480 490 500 510 520 550 560 570 580 590 600 hj0027 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN 530 540 550 560 570 580 610 620 630 640 650 660 hj0027 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: gi|386 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLL 590 600 610 620 630 640 670 680 690 700 710 720 hj0027 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY 650 660 670 680 690 700 730 740 750 760 770 780 hj0027 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF 710 720 730 740 750 760 790 800 810 820 830 840 hj0027 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL 770 780 790 800 810 820 850 860 870 880 890 900 hj0027 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV 830 840 850 860 870 880 910 920 930 940 950 960 hj0027 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW 890 900 910 920 930 940 970 980 990 1000 1010 1020 hj0027 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 hj0027 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 hj0027 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 hj0027 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 hj0027 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|386 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS 1190 1200 1210 1220 1230 1240 1270 1280 hj0027 YIGPSVNKAKSCATEERYKGTERERLLNF ::::::::::::::::::::::::::::: gi|386 YIGPSVNKAKSCATEERYKGTERERLLNF 1250 1260 1270 >>gi|114672573|ref|XP_001155285.1| PREDICTED: Niemann-Pi (1277 aa) initn: 7002 init1: 7002 opt: 8584 Z-score: 9538.8 bits: 1777.2 E(): 0 Smith-Waterman score: 8584; 98.826% identity (99.452% similar) in 1278 aa overlap (12-1289:1-1277) 10 20 30 40 50 60 hj0027 PPASAALRGHSMTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK : ::::::::::::::::::::::::::::::::::::::::::::::: gi|114 MIARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK 10 20 30 40 70 80 90 100 110 120 hj0027 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: gi|114 PLPKDGYDLVQELCPGFFFGNVSLCCDVQQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC 50 60 70 80 90 100 130 140 150 160 170 180 hj0027 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN 110 120 130 140 150 160 190 200 210 220 230 240 hj0027 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVRGMEPMNNATKGCDE :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|114 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDE 170 180 190 200 210 220 250 260 270 280 290 300 hj0027 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA 230 240 250 260 270 280 310 320 330 340 350 360 hj0027 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN 290 300 310 320 330 340 370 380 390 400 410 420 hj0027 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: gi|114 PGCVIFFSLVFITACSSGLVFVWVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI 350 360 370 380 390 400 430 440 450 460 470 480 hj0027 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL ::::::::: ::::::::::::::::::::::::::::::::::::: .::::::::::: gi|114 IRAPLTDKHTYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASSNNETVTLQDICL 410 420 430 440 450 460 490 500 510 520 530 540 hj0027 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL 470 480 490 500 510 520 550 560 570 580 590 600 hj0027 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN 530 540 550 560 570 580 610 620 630 640 650 660 hj0027 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLL ::::::::::.::::::::::::: :::::::::::::::::::::::::::.::::::: gi|114 FVKNYKNPNLSISFTAERSIEDELRRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLL 590 600 610 620 630 640 670 680 690 700 710 720 hj0027 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY 650 660 670 680 690 700 730 740 750 760 770 780 hj0027 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF 710 720 730 740 750 760 790 800 810 820 830 840 hj0027 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL 770 780 790 800 810 820 850 860 870 880 890 900 hj0027 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV :::::::::::.::::::::::::::::::::::::::::::.::::::::::::::::: gi|114 LKDWMRPIVIAVFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYVVDYFKSISQYLHAGPPV 830 840 850 860 870 880 910 920 930 940 950 960 hj0027 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW 890 900 910 920 930 940 970 980 990 1000 1010 1020 hj0027 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 hj0027 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM ::::::::::::::::: :.:::::::::::::::::::::::::::::::::::::::: gi|114 KCGKGGHAAYSSAVNIL-GNGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 hj0027 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 hj0027 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE ::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: gi|114 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSTKGSRVERAEE 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 hj0027 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS 1190 1200 1210 1220 1230 1240 1270 1280 hj0027 YIGPSVNKAKSCATEERYKGTERERLLNF ::::::::::::::::::::::::::::: gi|114 YIGPSVNKAKSCATEERYKGTERERLLNF 1250 1260 1270 >>gi|114672577|ref|XP_001155163.1| PREDICTED: Niemann-Pi (1261 aa) initn: 8422 init1: 7002 opt: 8419 Z-score: 9355.4 bits: 1743.3 E(): 0 Smith-Waterman score: 8419; 98.724% identity (99.362% similar) in 1254 aa overlap (12-1265:1-1253) 10 20 30 40 50 60 hj0027 PPASAALRGHSMTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK : ::::::::::::::::::::::::::::::::::::::::::::::: gi|114 MIARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK 10 20 30 40 70 80 90 100 110 120 hj0027 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: gi|114 PLPKDGYDLVQELCPGFFFGNVSLCCDVQQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC 50 60 70 80 90 100 130 140 150 160 170 180 hj0027 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN 110 120 130 140 150 160 190 200 210 220 230 240 hj0027 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVRGMEPMNNATKGCDE :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|114 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDE 170 180 190 200 210 220 250 260 270 280 290 300 hj0027 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA 230 240 250 260 270 280 310 320 330 340 350 360 hj0027 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN 290 300 310 320 330 340 370 380 390 400 410 420 hj0027 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: gi|114 PGCVIFFSLVFITACSSGLVFVWVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI 350 360 370 380 390 400 430 440 450 460 470 480 hj0027 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL ::::::::: ::::::::::::::::::::::::::::::::::::: .::::::::::: gi|114 IRAPLTDKHTYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASSNNETVTLQDICL 410 420 430 440 450 460 490 500 510 520 530 540 hj0027 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL 470 480 490 500 510 520 550 560 570 580 590 600 hj0027 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN 530 540 550 560 570 580 610 620 630 640 650 660 hj0027 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLL ::::::::::.::::::::::::: :::::::::::::::::::::::::::.::::::: gi|114 FVKNYKNPNLSISFTAERSIEDELRRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLL 590 600 610 620 630 640 670 680 690 700 710 720 hj0027 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY 650 660 670 680 690 700 730 740 750 760 770 780 hj0027 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF 710 720 730 740 750 760 790 800 810 820 830 840 hj0027 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL 770 780 790 800 810 820 850 860 870 880 890 900 hj0027 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV :::::::::::.::::::::::::::::::::::::::::::.::::::::::::::::: gi|114 LKDWMRPIVIAVFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYVVDYFKSISQYLHAGPPV 830 840 850 860 870 880 910 920 930 940 950 960 hj0027 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW 890 900 910 920 930 940 970 980 990 1000 1010 1020 hj0027 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 hj0027 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM ::::::::::::::::: :.:::::::::::::::::::::::::::::::::::::::: gi|114 KCGKGGHAAYSSAVNIL-GNGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 hj0027 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 hj0027 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE ::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: gi|114 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSTKGSRVERAEE 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 hj0027 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS 1190 1200 1210 1220 1230 1240 1270 1280 hj0027 YIGPSVNKAKSCATEERYKGTERERLLNF ::: : gi|114 YIGKSSHLKRVAQ 1250 1260 >>gi|114672571|ref|XP_001155116.1| PREDICTED: Niemann-Pi (1285 aa) initn: 7002 init1: 7002 opt: 8409 Z-score: 9344.1 bits: 1741.2 E(): 0 Smith-Waterman score: 8409; 97.327% identity (98.821% similar) in 1272 aa overlap (12-1282:1-1271) 10 20 30 40 50 60 hj0027 PPASAALRGHSMTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK : ::::::::::::::::::::::::::::::::::::::::::::::: gi|114 MIARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK 10 20 30 40 70 80 90 100 110 120 hj0027 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: gi|114 PLPKDGYDLVQELCPGFFFGNVSLCCDVQQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC 50 60 70 80 90 100 130 140 150 160 170 180 hj0027 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN 110 120 130 140 150 160 190 200 210 220 230 240 hj0027 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVRGMEPMNNATKGCDE :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|114 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDE 170 180 190 200 210 220 250 260 270 280 290 300 hj0027 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA 230 240 250 260 270 280 310 320 330 340 350 360 hj0027 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN 290 300 310 320 330 340 370 380 390 400 410 420 hj0027 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: gi|114 PGCVIFFSLVFITACSSGLVFVWVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI 350 360 370 380 390 400 430 440 450 460 470 480 hj0027 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL ::::::::: ::::::::::::::::::::::::::::::::::::: .::::::::::: gi|114 IRAPLTDKHTYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASSNNETVTLQDICL 410 420 430 440 450 460 490 500 510 520 530 540 hj0027 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL 470 480 490 500 510 520 550 560 570 580 590 600 hj0027 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN 530 540 550 560 570 580 610 620 630 640 650 660 hj0027 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLL ::::::::::.::::::::::::: :::::::::::::::::::::::::::.::::::: gi|114 FVKNYKNPNLSISFTAERSIEDELRRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLL 590 600 610 620 630 640 670 680 690 700 710 720 hj0027 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY 650 660 670 680 690 700 730 740 750 760 770 780 hj0027 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF 710 720 730 740 750 760 790 800 810 820 830 840 hj0027 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL 770 780 790 800 810 820 850 860 870 880 890 900 hj0027 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV :::::::::::.::::::::::::::::::::::::::::::.::::::::::::::::: gi|114 LKDWMRPIVIAVFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYVVDYFKSISQYLHAGPPV 830 840 850 860 870 880 910 920 930 940 950 960 hj0027 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW 890 900 910 920 930 940 970 980 990 1000 1010 1020 hj0027 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 hj0027 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM ::::::::::::::::: :.:::::::::::::::::::::::::::::::::::::::: gi|114 KCGKGGHAAYSSAVNIL-GNGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 hj0027 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 hj0027 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE ::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: gi|114 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSTKGSRVERAEE 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 hj0027 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS 1190 1200 1210 1220 1230 1240 1270 1280 hj0027 YIGPSVNKAKS-CATEERYKGTERERLLNF ::. .... : ... . .:. gi|114 YIAKLLERTIYLCISQHIHYATQMAPLQCLMTASDRR 1250 1260 1270 1280 >>gi|114672579|ref|XP_512062.2| PREDICTED: Niemann-Pick (1217 aa) initn: 7002 init1: 7002 opt: 8075 Z-score: 8973.0 bits: 1672.5 E(): 0 Smith-Waterman score: 8075; 98.748% identity (99.416% similar) in 1198 aa overlap (12-1209:1-1197) 10 20 30 40 50 60 hj0027 PPASAALRGHSMTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK : ::::::::::::::::::::::::::::::::::::::::::::::: gi|114 MIARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK 10 20 30 40 70 80 90 100 110 120 hj0027 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: gi|114 PLPKDGYDLVQELCPGFFFGNVSLCCDVQQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC 50 60 70 80 90 100 130 140 150 160 170 180 hj0027 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN 110 120 130 140 150 160 190 200 210 220 230 240 hj0027 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVRGMEPMNNATKGCDE :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|114 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDE 170 180 190 200 210 220 250 260 270 280 290 300 hj0027 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA 230 240 250 260 270 280 310 320 330 340 350 360 hj0027 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN 290 300 310 320 330 340 370 380 390 400 410 420 hj0027 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: gi|114 PGCVIFFSLVFITACSSGLVFVWVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI 350 360 370 380 390 400 430 440 450 460 470 480 hj0027 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL ::::::::: ::::::::::::::::::::::::::::::::::::: .::::::::::: gi|114 IRAPLTDKHTYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASSNNETVTLQDICL 410 420 430 440 450 460 490 500 510 520 530 540 hj0027 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL 470 480 490 500 510 520 550 560 570 580 590 600 hj0027 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN 530 540 550 560 570 580 610 620 630 640 650 660 hj0027 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLL ::::::::::.::::::::::::: :::::::::::::::::::::::::::.::::::: gi|114 FVKNYKNPNLSISFTAERSIEDELRRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLL 590 600 610 620 630 640 670 680 690 700 710 720 hj0027 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY 650 660 670 680 690 700 730 740 750 760 770 780 hj0027 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF 710 720 730 740 750 760 790 800 810 820 830 840 hj0027 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL 770 780 790 800 810 820 850 860 870 880 890 900 hj0027 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV :::::::::::.::::::::::::::::::::::::::::::.::::::::::::::::: gi|114 LKDWMRPIVIAVFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYVVDYFKSISQYLHAGPPV 830 840 850 860 870 880 910 920 930 940 950 960 hj0027 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW 890 900 910 920 930 940 970 980 990 1000 1010 1020 hj0027 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 hj0027 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM ::::::::::::::::: :.:::::::::::::::::::::::::::::::::::::::: gi|114 KCGKGGHAAYSSAVNIL-GNGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 hj0027 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 hj0027 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE ::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: gi|114 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSTKGSRVERAEE 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 hj0027 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS ::::::::: gi|114 ALAHMGSSVSTLSRATPAESHHKVILLSD 1190 1200 1210 >>gi|6581072|gb|AAF18444.1|AF202730_1 Niemann-Pick type (1286 aa) initn: 6603 init1: 6603 opt: 8071 Z-score: 8968.2 bits: 1671.7 E(): 0 Smith-Waterman score: 8071; 90.435% identity (97.512% similar) in 1286 aa overlap (4-1289:2-1286) 10 20 30 40 50 60 hj0027 PPASAALRGHSMTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK ::: :: ..::: :::::::::::::. :::::::::::: :::::::.:::::: gi|658 MSAAPRGGPVSARGRLLGLLLLLLCPAQVLPQSCVWYGECGIASGDKRYNCQYSGPPK 10 20 30 40 50 70 80 90 100 110 120 hj0027 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC :::::::::.::::::::: ::::::::.::::::::::::::::::::::::::.:::: gi|658 PLPKDGYDLIQELCPGFFFDNVSLCCDVQQLQTLKDNLQLPLQFLSRCPSCFYNLMNLFC 60 70 80 90 100 110 130 140 150 160 170 180 hj0027 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN :::::::::::::::::: ::::.::::::::::::::.:: ::.::::::::::::::: gi|658 ELTCSPRQSQFLNVTATEAYVDPATNQTKTNVKELQYYIGQRFADAMYNACRDVEAPSSN 120 130 140 150 160 170 190 200 210 220 230 240 hj0027 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVRGMEPMNNATKGCDE ::::::::::::.::::::::::::.:.::::::::::.:::.:::::::::::::::.: gi|658 DKALGLLCGKDANACNATNWIEYMFDKNNGQAPFTITPIFSDLPVRGMEPMNNATKGCNE 180 190 200 210 220 230 250 260 270 280 290 300 hj0027 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA .:::::.::::::::.:::::::::::: :: :.:::::::::::::::::..:::.::: gi|658 AVDEVTGPCSCQDCSVVCGPKPQPPPPPIPWRIFGLDAMYVIMWITYMAFLFMFFGTFFA 240 250 260 270 280 290 310 320 330 340 350 360 hj0027 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN :::::::::::::::::::::::::.:::::::::: ..::::::::::::::::::::: gi|658 VWCYRKRYFVSEYTPIDSNIAFSVNTSDKGEASCCDLLGAAFEGCLRRLFTRWGSFCVRN 300 310 320 330 340 350 370 380 390 400 410 420 hj0027 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI ::::::::: ::.:::::::.:::::::.::::::::::: .::.:: :::::::::::: gi|658 PGCVIFFSLGFIAACSSGLVYVRVTTNPIDLWSAPSSQARQDKEFFDAHFGPFFRTEQLI 360 370 380 390 400 410 430 440 450 460 470 480 hj0027 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL :::: :.:: ::::::::::::::::: :::::::::: :::.:::::.::::::::::: gi|658 IRAPHTNKHTYQPYPSGADVPFGPPLDKQILHQVLDLQTAIEDITASYNNETVTLQDICL 420 430 440 450 460 470 490 500 510 520 530 540 hj0027 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL ::::::: ::::::::::::::::.:::..:::::::::::::::::::.:::::::::: gi|658 APLSPYNKNCTILSVLNYFQNSHSMLDHEQGDDFFVYADYHTHFLYCVRVPASLNDTSLL 480 490 500 510 520 530 550 560 570 580 590 600 hj0027 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN ::::::::::::::::::::::::::::::::::::::.::::::::::::.:::::::: gi|658 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVSNYYNDTEKLQRAKAWEKEFIN 540 550 560 570 580 590 610 620 630 640 650 660 hj0027 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLL :::::.::::::::::::::::::.:::.:::::::::::.:::::::::::.:::::.: gi|658 FVKNYENPNLTISFTAERSIEDELDRESNSDVFTVVISYAVMFLYISLALGHIKSCRRFL 600 610 620 630 640 650 670 680 690 700 710 720 hj0027 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY ::::::::::::::::::::::::.:::::.:::::::::::::::::::::::::::.: gi|658 VDSKVSLGIAGILIVLSSVACSLGIFSYIGIPLTLIVIEVIPFLVLAVGVDNIFILVQTY 660 670 680 690 700 710 730 740 750 760 770 780 hj0027 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF :::::::::::::::::::::::::.:::::.::::::::.:::::::::::::::.::: gi|658 QRDERLQGETLDQQLGRVLGEVAPSIFLSSFAETVAFFLGGLSVMPAVHTFSLFAGMAVF 720 730 740 750 760 770 790 800 810 820 830 840 hj0027 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL ::::::::::::::::::::::::.::..:: :::: :::.::::: ::::::::::::: gi|658 IDFLLQITCFVSLLGLDIKRQEKNQLDVLCCFRGAEAGTSIQASESYLFRFFKNSYSPLL 780 790 800 810 820 830 850 860 870 880 890 900 hj0027 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV :::::::::::.:::::::::::::::.::::::::::::::.::::::..::::::::: gi|658 LKDWMRPIVIAVFVGVLSFSIAVLNKVEIGLDQSLSMPDDSYVVDYFKSLGQYLHAGPPV 840 850 860 870 880 890 910 920 930 940 950 960 hj0027 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW ::::::::.::: .::::::::.::.:::::::::::::::::::::::::::::::::: gi|658 YFVLEEGHNYTSLQGQNMVCGGLGCDNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW 900 910 920 930 940 950 970 980 990 1000 1010 1020 hj0027 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP ::::::::::.:.:.:::::::::::::::::::::::::::: :::::::::::::::: gi|658 VKPQSSCCRVSNVTEQFCNASVVDPACVRCRPLTPEGKQRPQGEDFMRFLPMFLSDNPNP 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 hj0027 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM ::::::::::..::::: :.::.::::::::::::::::::::::.:::.:::.:.: :: gi|658 KCGKGGHAAYGTAVNIL-GNGTEVGATYFMTYHTVLQTSADFIDAMKKAQLIAGNATATM 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 hj0027 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA :..:: ::::::::::::::::::.::..:::::::::.:.:..::::::::::::::. gi|658 GLKGSRCRVFPYSVFYVFYEQYLTILDDAVFNLGVSLGAVFVVAVVLLGCELWSAVIMCV 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 hj0027 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE ::.:.:::::::::::::::::::::::::::::::::::::::::::: ::::: :::: gi|658 TITMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSGKGSRVARAEE 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 hj0027 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|658 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS 1200 1210 1220 1230 1240 1250 1270 1280 hj0027 YIGPSVNKAKSCATEERYKGTERERLLNF :::::.::::::::.:::::::::::::: gi|658 YIGPSTNKAKSCATQERYKGTERERLLNF 1260 1270 1280 >>gi|20531742|gb|AAM27451.1| Niemann-Pick C1 [Felis catu (1276 aa) initn: 7083 init1: 5589 opt: 8048 Z-score: 8942.7 bits: 1666.9 E(): 0 Smith-Waterman score: 8048; 90.923% identity (97.731% similar) in 1278 aa overlap (12-1289:1-1276) 10 20 30 40 50 60 hj0027 PPASAALRGHSMTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPK ::::: ::::::::::::::..:::.:::::::: :::::::.:::::: gi|205 MTARGPALGLLLLLLCPAQVLAQSCIWYGECGIASGDKRYNCKYSGPPK 10 20 30 40 70 80 90 100 110 120 hj0027 PLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFC ::::::::::::::::::: ::::::::.::::::::::::::::::::::::::.:::: gi|205 PLPKDGYDLVQELCPGFFFDNVSLCCDVQQLQTLKDNLQLPLQFLSRCPSCFYNLVNLFC 50 60 70 80 90 100 130 140 150 160 170 180 hj0027 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSN ::::::::::::::::::::::::::::::::::::::.:.::::::::::::::::::: gi|205 ELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYIGESFANAMYNACRDVEAPSSN 110 120 130 140 150 160 190 200 210 220 230 240 hj0027 DKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVRGMEPMNNATKGCDE ::::::::::::.::::::::::::.::::::::::::.:::.:..:::::::::::::: gi|205 DKALGLLCGKDAEACNATNWIEYMFSKDNGQAPFTITPIFSDLPTHGMEPMNNATKGCDE 170 180 190 200 210 220 250 260 270 280 290 300 hj0027 SVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFA ::::::.:::::::::::::::::::::.:: :::::::::::::::::::::::::::: gi|205 SVDEVTGPCSCQDCSIVCGPKPQPPPPPVPWRILGLDAMYVIMWITYMAFLLVFFGAFFA 230 240 250 260 270 280 310 320 330 340 350 360 hj0027 VWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRN .:::::::::::::::::::::::::.:.::::::: ..:::::::::::..:::::::: gi|205 LWCYRKRYFVSEYTPIDSNIAFSVNANDRGEASCCDALGAAFEGCLRRLFSQWGSFCVRN 290 300 310 320 330 340 370 380 390 400 410 420 hj0027 PGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLI :: .:::::.::.:::::::::::::::::::::::::::::::::: :::::::::::: gi|205 PGPIIFFSLAFIAACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDTHFGPFFRTEQLI 350 360 370 380 390 400 430 440 450 460 470 480 hj0027 IRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL :.:: :. : :::::::.:::::::::. ::::::::: :::::::::.::::::::::. gi|205 IQAPHTSAHTYQPYPSGSDVPFGPPLDLAILHQVLDLQTAIENITASYNNETVTLQDICV 410 420 430 440 450 460 490 500 510 520 530 540 hj0027 APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLL ::::::: ::::::::::::::::.:::. :::::::::::::.:::::::::::::::: gi|205 APLSPYNKNCTILSVLNYFQNSHSMLDHEIGDDFFVYADYHTHLLYCVRAPASLNDTSLL 470 480 490 500 510 520 550 560 570 580 590 600 hj0027 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFIN ::::::::::::::::::::::::::::::::::::::::::::::.::.:..::::::: gi|205 HDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTERLQKAHVWEKEFIN 530 540 550 560 570 580 610 620 630 640 650 660 hj0027 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLL :::::::::::::::.::::::::::::..:.:::.:::::::::::.::::.::: ::: gi|205 FVKNYKNPNLTISFTTERSIEDELNRESNGDIFTVIISYAIMFLYISIALGHIKSCSRLL 590 600 610 620 630 640 670 680 690 700 710 720 hj0027 VDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY ::::.:::::::::::::::::::.:::.:.:::::::::::::::::::::::::::.: gi|205 VDSKISLGIAGILIVLSSVACSLGIFSYVGIPLTLIVIEVIPFLVLAVGVDNIFILVQTY 650 660 670 680 690 700 730 740 750 760 770 780 hj0027 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF ::::::.::::::::::::::::::::::::::.::::::::: ::::::::::::.::. gi|205 QRDERLHGETLDQQLGRVLGEVAPSMFLSSFSEAVAFFLGALSKMPAVHTFSLFAGMAVL 710 720 730 740 750 760 790 800 810 820 830 840 hj0027 IDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLL :::::::::::::::::::::::::::..:::::.:::::::::::::::.::.:::::: gi|205 IDFLLQITCFVSLLGLDIKRQEKNRLDVLCCVRGSEDGTSVQASESCLFRLFKHSYSPLL 770 780 790 800 810 820 850 860 870 880 890 900 hj0027 LKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPV ::::::::::::::::::::.::::::.::::::::::::::..:::::. .:::::::: gi|205 LKDWMRPIVIAIFVGVLSFSVAVLNKVEIGLDQSLSMPDDSYVMDYFKSL-KYLHAGPPV 830 840 850 860 870 880 910 920 930 940 950 960 hj0027 YFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDW :::::::::::: ::::::::::::::::::::::::::::.:::::::::::::::::: gi|205 YFVLEEGHDYTSLKGQNMVCGGMGCNNDSLVQQIFNAAQLDSYTRIGFAPSSWIDDYFDW 890 900 910 920 930 940 970 980 990 1000 1010 1020 hj0027 VKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNP :::::::::: : ::.:::::::::::.:::::: ::::::::::::::::::::::::: gi|205 VKPQSSCCRVYNSTDRFCNASVVDPACIRCRPLTQEGKQRPQGGDFMRFLPMFLSDNPNP 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 hj0027 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM ::::::::::::::::: :. : ::::::::::::::::::: ::..:: :::::.:.:: gi|205 KCGKGGHAAYSSAVNIL-GNDTGVGATYFMTYHTVLQTSADFTDAMRKANLIASNITKTM 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 hj0027 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA :..:: :::::::::::::::::::::::::::.::::::::::..::::.:::::::: gi|205 GLEGSNYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGAIFLVTVILLGCDLWSAVIMCI 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 hj0027 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEE ::::.:::::::::::::::::::::::::::::::::::::::::::::::::..:::: gi|205 TIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRAQRAEE 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 hj0027 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|205 ALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS 1190 1200 1210 1220 1230 1240 1270 1280 hj0027 YIGPSVNKAKSCATEERYKGTERERLLNF :::::.::::: ::.:.:::::::.:::: gi|205 YIGPSINKAKSLATQEQYKGTEREQLLNF 1250 1260 1270 1289 residues in 1 query sequences 2362217958 residues in 6843189 library sequences Tcomplib [34.26] (8 proc) start: Tue Aug 12 13:24:15 2008 done: Tue Aug 12 13:26:33 2008 Total Scan time: 1174.860 Total Display time: 1.040 Function used was FASTA [version 34.26.5 April 26, 2007]