ORK06739

Kazusa Clone (Original Type)

Gene/Protein Characteristic Table for ORK06739

Order Kazusa clone(s) from :

Accession No	AB208866
Product ID	ORK06739
Clone name	hg02374
Vector information	The cDNA fragment was inserted at the SalI-NotI site of the ... The cDNA fragment was inserted at the SalI-NotI site of the pBluescript II SK(+) vector (GenBank Accession No. X52328). The 5' end of the cDNA was repaired and ligated with the SalI adapter (5'TCGACCCACGCGTCCG3') and inserted at the SalI site of the vector. The 3'end of the cDNA was inserted at the NotI site of the vector.
Symbol	SCN5A
cDNA sequence	DNA sequence (7021 bp) Predicted protein sequence (1576 aa)
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

Features of the cloned cDNA sequence

Description

Length: 7021 bp

Physical map

Restriction map

Prediction of protein coding region (GeneMark analysis) for : cloned DNA seq.

Warning for N-terminal truncation: YES

Warning for coding interruption : NO

Integrity of 3' end

Length of 3'UTR	2289 bp
Genome contig ID	gi89161205r_38464552
PolyA signal sequence (AATAAA,-23)	+--------+--------+----*----+---- TTAAAACAAACCAATAAATGGCTTACATGACCTGG
Flanking genome sequence (100000 - 99951)	----+--------+--------+--------+--------+----* TCTAGGCTCTGTCCTTGTGCTGAGATTTGACAAGAGTGGTAGCAGAGGAC

Features of the protein sequence

Description

Length: 1576 aa

Result of homology search against nr database (FASTA output, Multiple alignment)

Entry	ID%	Protein	Source
BAD92103	100.0	voltage-gated s...	Homo sapiens
NP_001092875	99.8	sodium channel ...	Homo sapiens
ABR15764	99.3	Nav1.5 Na+ chan...	Homo sapiens
XP_001917236	93.0	voltage-gated s...	Equus caballus
AAN61120	98.8	cardiac sodium ...	Homo sapiens

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of motif / domain search (InterProScan and SOSUI)

[ zoom out (x2) ]

Result of InterProScan

Search method	interpro_ID	From	To	Entry	Definition
FPrintScan	IPR008053	23	37	PR01666	Na+ channel 5
	IPR008053	84	104	PR01666	Na+ channel 5
	IPR008053	206	223	PR01666	Na+ channel 5
	IPR008053	553	571	PR01666	Na+ channel 5
	IPR008053	602	618	PR01666	Na+ channel 5
	IPR001696	1314	1333	PR00170	Na+ channel
	IPR001696	1349	1362	PR00170	Na+ channel
HMMPfam	IPR005821	330	517	PF00520	Ion transport
	IPR010526	530	793	PF06512	Sodium ion transport-associated
	IPR005821	819	1029	PF00520	Ion transport
	IPR005821	1122	1331	PF00520	Ion transport
	IPR000048	1462	1482	PF00612	IQ calmodulin-binding region

Prediction of transmembrane (TM) segments

Method	No.	N terminal	transmembrane region	C terminal	type	length
SOSUI2	1	298	TDLTITMCIVLNTLFMALEHYN	319	SECONDARY	22
	2	359	GWNIFDSIIVILSLMELGLSRMS	381	SECONDARY	23
	3	387	RSFRLLRVFKLAKSWPTLNTLIK	409	SECONDARY	23
	4	411	IGNSVGALGNLTLVLAIIVFIFA	433	PRIMARY	23
	5	460	MMDFFHAFLIIFRILCGEWIETM	482	PRIMARY	23
	6	498	FLLVMVIGNLVVLNLFLALLLSS	520	PRIMARY	23
	7	785	FETFIIFMILLSSGALAFEDIYL	807	PRIMARY	23
	8	817	LEYADKMFTYVFVLEMLLKWVAY	839	SECONDARY	23
	9	847	NAWCWLDFLIVDVSLVSLVANTL	869	PRIMARY	23
	10	906	VGAIPSIMNVLLVCLIFWLIFSI	928	PRIMARY	23
	11	1008	IYFVIFIIFGSFFTLNLFIGVII	1030	PRIMARY	23
	12	1089	AFDVTIMFLICLNMVTMMVETDD	1111	SECONDARY	23
	13	1119	ILAKINLLFVAIFTGECIVKLAA	1141	SECONDARY	23
	14	1150	SWNIFDFVVVILSIVGTVLSDII	1172	PRIMARY	23
	15	1183	RVIRLARIGRILRLIRGAKGIRT	1205	SECONDARY	23
	16	1210	LMMSLPALFNIGLLLFLVMFIYS	1232	PRIMARY	23
	17	1251	MFNFQTFANSMLCLFQITTSAGW	1273	SECONDARY	23
	18	1309	ILFFTTYIIISFLIVVNMYIAII	1331	PRIMARY	23